Retrospective Evaluation of Childhood Cutaneous Mastocytosis Cases
Journal Title: The Journal of Pediatric Research - Year 2020, Vol 7, Issue 1
Abstract
Aim: Mastocytosis is a rare disease characterized by clonal mast cell proliferation in one or more organs. It can lead to different clinical manifestations and has no definitive treatment. In this study, we aimed to evaluate the clinical and laboratory characteristics of our patients diagnosed with mastocytosis in our clinic. Materials and Methods: Thirteen patients that were followed up with the diagnosis of mastocytosis at the Pediatric Hematology Clinic, in the Ege University Faculty of Medicine between November 1999 and April 2016 were retrospectively analyzed. Results: Seven of patients were female (53.8%) and six were male (42.6%). The mean age at diagnosis was 20 (3-68) months. At the time of diagnosis, complete blood count and peripheral smear were found to be compatible with the anemia of iron deficiency in three patients. Other parameters were normal. Mean tryptase level was detected as 5.9 (3.6-16.6) ng/mL, and only one tryptase level was found as slightly increased. The median level of total IgE was 91.1 (4.47-362) IU/mL. Mast cell proliferation was not detected in bone marrow aspiration and biopsy material of any patients. All of the cases were evaluated as cutaneous type mastocytosis. Conclusion: The possibility of mastocytosis in systemic form in childhood is very rare and bone marrow examination may be necessary in selected cases.
Authors and Affiliations
Burcu Akıncı, Hamiyet Hekimci Özdemir, Nihal Özdemir Karadaş, Akkız Şahin Yaşar, Zuhal Önder Siviş, Yeşim Aydınok, Kaan Kavaklı, Can Balkan, Deniz Yılmaz Karapınar
Keywords
Related Articles
- EP ID EP685464
- DOI 10.4274/jpr.galenos.2019.98105
- Views 130
- Downloads 0
An Investigation of Pediatric Nurses’ Oral Care Practices
Aim: Oral care is a standard practice used to reduce ventilator-associated pneumonia in intensive care units and in the treatment of chemotherapy-induced oral mucositis. This research examines the oral care practices of...
The Role of Alvarado and Pediatric Appendicitis Score in Acute Appendicitis in Children
Aim: Acute appendicitis (AA) is the condition that most commonly requires a surgical procedure in children presenting to the emergency department with acute abdominal pain. Alvarado and Pediatric Appendicitis scores (PAS...
Successful Orthotopic Heart Transplantation in Patients with Becker Muscular Dystrophy
Cardiomyopathy is a major factor contributing to mortality and morbidity in patients with Duchenne and Becker muscular dystrophies (DMD/BMD), and is therefore among the increasingly important findings. These X-linked rec...
Paediatric Rhegmatogenous Retinal Detachment: Clinical Features and Surgical Outcomes
Aim: To evaluate the clinical characteristics, predisposing factors and surgical outcomes of rhegmatogenous retinal detachment (RRD) in paediatric patients. Materials and Methods: This retrospective consecutive case ser...
Hereditary Neuropathy with Liability to Pressure Palsy: A Case Diagnosed with a Quick Multiplex Ligation-dependent Probe Amplification Test
Hereditary neuropathy with a liability to pressure palsies (HNPP) represented by recurrent focal pressure neuropathies is rare in childhood. Here we present a 10-year-old girl admitted to our hospital with a recurrent we...