REVERSAL OF HYPERMETHYLATION AND REACTIVATION OF TUMOR SUPPRESSOR GENES DUE TO NATURAL COMPOUNDS IN BREAST CANCER CELLS
Journal Title: International Journal of Biological Innovations - Year 2020, Vol 2, Issue 1
Abstract
Breast oncogenesis is a multistage process that involves epigenetic and genetic changes. Epigenetics is outlined as reversible changes in gene expression, with no alteration in gene sequence. DNA methylation, histone modification, and nucleosome transformation are the foremost epigenetic changes that may get dysregulated in breast cancer. Epigenetic silencing of tumor suppressor genes (TSGs) is reversed by varied molecules as well as natural compounds like polyphenols which will act as a hypermethylation agent. Nowadays, much of the research is going in the direction of natural and dietary compounds and attempting to search out novel and extra effective medical aid for the breast cancer patients. In this literature, few vital natural chemical compounds effective against the breast oncogenesis with their mode of actions are discussed. Such chemicals act as an analytical and prognostic tool in breast cancer due to their role in epigenetic regulation.
Authors and Affiliations
Debasray Saha, Neeraj Vaishnav, Zubiya Ahsan, Nisha Rani, Runjhun Mathur and Abhimanyu Kumar Jha
Keywords
Related Articles
- EP ID EP683530
- DOI https://doi.org/10.46505/IJBI.2020.2109
- Views 279
- Downloads 0
Assessment of Current Competency Level of Agricultural Extension Advisors in Federal Nepal.
In the present context of 21st century, modernization in the agriculture sector demands a higher level of competency to fulfill the needs and wants of people around the globe. Competency is amalgamation of skills, knowle...
Detection of Pollutants present in the surface water of Ayad River, Udaipur, Rajasthan.
The present study focuses on detection of pollutants in the Ayad River flowing through Udaipur city in Rajasthan (India). Water samples from three different locations of the river were collected and analyzed over a per...
Comparative morphometric, meristic and osteological studies on adult and young hilsa (Tenualosa ilisha).
Tenualosa ilisha (matured/adult) and jatka (immature/young), locally known as Ilish, is designated as the national fish of Bangladesh. Both the stages were collected from different fish markets from Savar, Bangladesh dur...
An insight highlight story on the beneficial and phytochemical impact of Prosopis cineraria in Tonk, Rajasthan (India).
Prosopis cineraria belongs to the family Mimosaceae. Traditionally the tribal people use Prosopis cineraria in their daily diet. Its leaves, pods and bark have many significant phytochemical components. It is used trad...
Impact of sound pollution on animal and human health.
At present, noise pollution is considered as one of the key problems which have numerous detrimental effects on both physical and social environment. Noise menace has negative bearing on both health and environment. Ri...