REVIEW ON PHORBOL ESTER DEGRADATION OF JATROPHA SEED CAKE FOR ITS USE AS ANIMAL FEED
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2017, Vol 9, Issue 1
Abstract
Jatropha curcas is an oil-seed plant with good adaptability to grow in unfavourable conditions like infertile soil with scanty rainfall. It had been exploited for the extraction of oil for bio-diesel. The compressed seed cake, after the oil extraction, is a rich source of protein with certain toxic and anti-nutritional factors. The major toxins in the seed cake are phorbol esters and trypsin inhibitors that lead to various health problems if ingested. Even though the application of the various extracts carries a lot of beneficial advantages, yet the toxicity in oil and the compressed cake does not allow the by-products and the oil to be used elsewhere. Various physicochemical and biological methods have been described for the detoxification of Jatropha seed cake and oil of which the chemical extraction with methanol and ethanol have shown promising results in reducing the toxin contents by 97-100% while UV-irradiation reduced the phorbol esters completely. Submerged fermentation by Bacillus sp. achieved complete detoxification of phorbol esters within a week. A new strain was found to degrade the phorbol esters to phorbol, myristic acid and acetic acid within 12 h of incubation in submerged fermentation process. The detoxified products, in future, can be used as animal feed and food supplement to help utilize the by-products as a healthy diet.
Authors and Affiliations
Shilpi Ahluwalia, Rajkumar Bidlan, Jai Gopal Sharma, Pushpendra Singh
Keywords
Related Articles
- EP ID EP575739
- DOI 10.22159/ijpps.2017v9i1.15380
- Views 61
- Downloads 0
DEVELOPMENT AND VALIDATION OF HPLC/UV METHOD FOR DETERMINATION OF MELOXICAM IN HUMAN PLASMA AND APPLICATION IN PHARMACOKINETIC STUDIES
Objective: To develop and validate a modified isocratic reversed-phase high performance liquid chromatographic/ultraviolet (RP-HPLC/UV) method for determination of Meloxicam in human plasma to be used for pharmacokinetic...
ANTIOBESITY ACTIVITY OF ETHANOLIC EXTRACT OF CASSIA AURICULATA IN HIGH FAT DIET INDUCED OBESE RATS
Objective: The present work was undertaken to evaluate the effect of Cassia auriculata leaves extract in high fat diet induced obesity in rats.Methods: Male Wistar rats weighing 150-200 g were divided into orlistat stand...
EFFECT OF AMLODIPINE AND ENALAPRIL ON WOUND HEALING IN DIABETIC WISTAR ALBINO RATS
Objective: A number of structural and functional mechanisms have been identified in the pathogenesis of impaired wound healing in diabetes. Diabetes promotes endothelial dysfunction as evidenced by decreased nitric oxide...
PRETREATMENT VARIATIONS IN HAEMATOLOGICAL PARAMETERS OF BREAST CANCER PATIENTS
Objective: The objective of the presented study was to analyze the haematological parameters in female breast cancer (BC) patients before the start of the treatment.Methods: The study was conducted among female BC patien...
SYNTHESIS OF NOVEL γ-CARBOLINE DERIVATIVES AND THEIR IN SILICO STUDIES ON 5HT1, H1 AND CCR2 ANTAGONIST RECEPTORS
Objective: Synthesis of novel γ-carboline precursor 4 by using mild, inexpensive and eco friendly T3Methods: The reaction was carried out by taking mixture of 1 equiv. of phenyl hydrazine hydrochloride, 1 equiv. of N-Bo...