Role of Autologous Stem Cell Therapy in Asherman’s Syndrome and Thin Endometrium: A Case Series
Journal Title: Scholars Journal of Medical Case Reports - Year 2017, Vol 5, Issue 5
Abstract
Stemcells are the cells that perpetually produce another alike cells (self renewal) and have the capacity to differentiate in to diverse cell types if need arise, in all multi-cellular organisms for repair and regeneration of damaged tissue. Lately group of epithelial progenitor cells and mesenchymal stromal cells were found to be responsible for regenerating the functional layer of endometrium after menstruation and parturition. Any injury, surgery, trauma, or infection can damage to the endometrial lining thus causing scarring and fibrosis of endometrium along with thinning of endometrium which is known as Asherman’s syndrome. Thus transplantation of mesenchymal stem cells[MSCs] and hematopoietic stem cell[HSCs] in the uterus along with growth factors will help in regeneration of endometrium with healing of fibrosis.The purpose of this study is to evaluate whether autologous stem cell transplantation in uterus may improve endometrial thickness and reduce scarring in case of Asherman’s syndrome. Five married women with secondary sterility with amenorrhoea in 2 patients and scanty and irregular menses in 3 patients due to endometrial factorwere selected on the basis of clinical features and investigations, who have been treated for Asherman’s syndrome by different modalities with no avail and were, advised surrogacy. MSCS & HSCs were implanted at endometrial (basal layer) myometrial junction, at 3- 4 sites, Endometrial response was assessed by USG at monthly interval. All 5 patients got relief in term of resuming menstruation, in 2 amenorrhoeicpt; rest 3 patients have improvement in menstrual flow. Adult Autologous MSCs & HSCs transplantation in uterus helps in reversal of chronic inflammatory changes with re-growth of endometrium, in turn improved symptoms & prospect of fertility. Keywords:Adult autologous stem cells, MSCs, HSCs, endometrial regeneration, Asherman’s syndrome, growth factors
Authors and Affiliations
DrSapna Jain, DrMayank Jain, DrAstha Gupta, DrMannan gupta, DrPoonam Verma
Keywords
Related Articles
- EP ID EP379234
- DOI -
- Views 82
- Downloads 0
Atypical Bilateral Mooren Ulcer Following Small Incision Lenticule Extraction (SMILE)
A 38-year-old Malay gentleman presented with 1 year history of bilateral eye discomfort and redness with deteriorating vision. He underwent myopic laser refractive surgery and had history of ocular Steven Johnsons syndro...
Unusual Presentation of A Frontal Arteriovenous Malformation
The intracranial hypertension (ICH) is an unusual consequence of the unruptured arteriovenous malformation (AVM), only 13 cases are described in the literature. We report in this observation a case of unruptured AVM reve...
Carcinoma Caecum Misdiagnosed as Appendicitis: A Case Report
A 20 years young male presented with history of pain right lower abdomen for 3 months. Pain was intermittent, colicky in nature. There was history of nausea and occasional episodes of vomiting. On detailed history he had...
“What’s wrong With Me…”- A Case Report of Borderline Personality Disorder
Patients with borderline personality disorder (BPD) stand on the border between neurosis and psychosis, and they are characterized by extraordinarily unstable affect, mood swing, behavior, object relations, and self-imag...
Pane of the Sternal Manubrium-Case Report
Sternal fractures are rare and mainly caused by a direct impact on the anterior aspect of the thorax. In most cases, sternal fractures are treated conservatively. However, if the patient has symptoms such as refractory w...