Role of biomarker of Oxidative stress in preeclampsia
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2016, Vol 3, Issue 3
Abstract
Objective: To evaluate the role of biomarker of oxidative stress in predilection of pregnancy induced hypertension. Material and Methods: A sample of 200 pregnant women was examined at department of Gynecology and obstetrics at tertiary care hospital from the period of July 2008 to march 2010. Pregnant women were divided into three groups including 100 normal healthy pregnant women which were controls. Another 100 pregnant women having increased blood pressure and proteinuria divided into two groups depend on severity on B.P. and urinary proteinuria. Groups were compared for the levels of antioxidant biomarker for the statistical analysis, suitable test for these qualitative variables with 5% significance were used. Results: Preeclampsia remains a frequent and potentially dangerous complication of pregnancy. The cause remains largely unknown, but oxidative stress and a generalized inflammatory state common are features. In present study, patient with pregnancy induced hypertension shows MDA levels were found significantly higher, while Vitamin C and Vitamin E levels are significantly lower compared with normal healthy pregnant women. Conclusion: A combination of vitamins C and E administration can be found promising for prevention of preeclampsia. As small study group, our study has a limited statistical power if significance several multicenter randomized clinical trials are further required.
Authors and Affiliations
Smita Bahediya, Gaurav Modi, Shobha Chokshi
Keywords
Related Articles
- EP ID EP242801
- DOI -
- Views 81
- Downloads 0
Role of free radicals and antioxidants in cervical cancer in southern part of Rajasthan
Introduction Present study is conducted to measure the role of free radicals malondialdehyde and vitaminC and vitaminE in cervical cancer women in southern part of RajasthanMaterials and Methods Total 80 cases and contro...
Study of serum copper and zinc levels in association with albumin and uric acid as antioxidant markers in type II diabetes mellitus
Introduction: Type II Diabetes mellitus (type II DM) is a chronic metabolic disorder characterised by oxidative stress. Free radicals play a pivotal role in the progression of diabetes and its complications. The role of...
Liver enzymes and glycemic control markers in uncontrolled type 2 diabetes mellitus- A case control study
Introduction: Mild increase in liver enzymes, may be a marker for significant liver injury. The increased transaminases and hepatomegaly are found to be reversible with glycemic control. Objectives: 1. To compare the liv...
Erythrocyte glutathione peroxidase levels in hyperthyroidism–effect of treatment with methimazole
Background: The hypermetabolic state seen in hyperthyroidism causes increased oxygen consumption resulting in an increased formation of Reactive Oxygen Species leading to tissue injury. Increased oxidative stress charact...
Role of Glycemic control and Lipid profiles in management of Diabetic complications
Background & Objectives: Diabetes mellitus is one of the most common endocrine disorders affecting about 6% of the world’s population. Diabetes mellitus is the leading cause of end stage renal disease (ESRD), a major cau...