Role of C - R eactive protein In Carcinoma Esophagus In Terms Of Survival And Disease Free Progression
Journal Title: International Journal of Scientific Research and Management - Year 2017, Vol 5, Issue 12
Abstract
Background: Cancer esophagus carries very poor prognosis. Patients usually present at an advanced stage, when curative options are very limited. There is no independent predictive marker, currently available which may indicate the general status of the patient prior to treatment. Keeping in view the poor outcome and great load of this diseases in this part of country, we conducted this study to find out the significance of C - reactive protein levels in our set of patients. Material and me thods: A total of 153 patients with histologically confirmed carcinoma esophagus, were enrolled in the study between November 2013 to May 2015.Patient’s eligibility included Squamous cell carcinoma histology, No prior treatment in the form of surgery, chem otherapy or radiotherapy. History of the patient was thoroughly taken to rule out any chronic illness. Besides CBC, biochemistry, imaging modalities used for staging workup, serum C - reactive protein levels were determined in all patients prior to treatment . Results : In a group with CRP levels < 6mg/l, 44 (34.37%) had partial response, 42 (32.81%) had disease progression, while in group with CRP levels > 6 mg/l, 66.66% had disease progression, which was statistically significant (p=0.003). At 6 months of fo llow up, 95 (62.09%) patientswere lost to follow up and 12 (7.3%) had expired. 46 patients were available for further analysis. 35 patients with CRP levels< 6mg/l, showed partial response and disease progression on endoscopy and CECTof chest findings in42. 85% and 40% of cases respectively and 11 patients withCRP levels >6 mg/l, had disease progression in 72.72% of cases (p=0.06). Conclusion: Elevated C - reactive protein levels are associated with tumor progression and poor survival in patients with squamous cell carcinoma of esophagus
Authors and Affiliations
Khan NA
Keywords
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