Role of Diffusion Mri In Differentiation Between The Common Pediatric Posterior Fossa Brain Tumors.
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 73, Issue 2
Abstract
<strong>Background:</strong> Diffusion weighted imaging (DWI) and apparent diffusion coefficient (ADC) map provide information on MRI about the cellularity of the tumor and have an important role in the pre-operative differentiation of different tumor types.<br /> <strong>Objective: </strong>The aim of this work is to assess the role of diffusion MRI in differentiation between the most frequently encountered pediatric posterior fossa brain tumors.<br /> <strong>Materials and methods: </strong>Twenty-four patients were prospectively included in this study. They were referred from the Neurosurgery Department. All of them were suspected to have posterior fossa SOL according to the contrast enhanced CT. All patients were subjected to conventional MRI followed by diffusion MR imaging and calculation of the ADC values.<br /> <strong>Results: </strong>Twenty-four children (15 females) were included in the study. Their ages ranged between one and fifteen years old with a mean age of six years. Low-and high-grade tumors could be differentiated by using both absolute ADC values and ratios. Low-grade tumors showed statistically significantly higher ADC values (1.69±0.15 vs. 0.80±0.23) and ratios for tumor versus normal cerebellum (2.17±0.30 vs. 1.14±0.33) and tumor versus brain stem (1.88±0.35 vs. 1.06±0.24).The probability of error at 0.05 was considered significant, while at 0.01 and 0.001 was considered highly significant. Absolute ADC values and cerebellar and brainstem ratios were significantly higher in low-grade astrocytomas than in MBs. Overlap was found between ADC values of ATRTs and MBs.The sensitivity and specificity of a cutoff ADC value of > 1.083 x 10<sup>-3</sup>mm<sup>2</sup>/s for differentiation of pilocytic astrocytomas from MBs and ependymomas were 100%.The sensitivity and specificity of a cutoff ADC value of ≤ 0.847 x 10<sup>-3</sup>mm<sup>2</sup>/s for differentiation of medulloblastomas from PAs and ependymomas were 100%.The sensitivity and specificity of a cutoff ADC value of ≤ 1.083 x 10<sup>-3</sup>mm<sup>2</sup>/s and > 0.847 x 10<sup>-3</sup>mm<sup>2</sup>/s for ependymomas were 100%.<br /> <strong>Conclusion: </strong>The calculation of ADC value in the solid enhancing portion of a tumor is a simple and reliable technique for preoperative differentiation of the most common posterior fossa tumors.<br /> <strong> </strong>
Authors and Affiliations
Eman Helal
Keywords
Related Articles
- EP ID EP584444
- DOI 10.12816/ejhm.2018.12521
- Views 98
- Downloads 0
Evaluation of Knowledge, Attitude and Practice of Epistaxis among the General Population of Tabuk City, Saudi Arabia
Background: epistaxis is a fairly common problem, which has been reported to be occurring in about 60% of the population. It defined as a bleeding from nose or nasal cavity and it is considered as one of the most common...
First Line Management of Adult Diabetic Ketoacidosis Patients
Abstract Background:Diabetic Ketoacidosis (DKA) is a hyperglycemic crisis that can occur in patients with both type 1 and 2 diabetes mellitus. It is a medical emergency with a significant morbidity and mortality. It is h...
Outcome of Endovascular Treatment of Cerebral Arteriovenous Malformations with Ethylene Vinyl Alcohol Coploymer
<strong>Background: </strong>Cerebral AVMs are very rare lesions, and this rarity contributes to the difficulty of treating them. There is no consensus concerning the method of treatment to be chosen among neurosurgery,...
Pattern of Thyroid Diseases in Arar City, Northern Saudi Arabia
<strong>Background:</strong> Thyroid hormone acts as a vital factor of development and growth, and in adults plays a critical part in the regulation of the function and metabolism of virtually every organ system. <strong...
Role of dynamic MRI in assessment of Pelvic Floor Dysfunction in Females
<span>Introduction: </span><span>Pelvic floor dysfunction is a major medical and social problem. Dynamic MR imaging of the pelvic floor is an excellent tool for assessing functional disorders of the pelvic floor. Finding...