Role of glial fibrillary acidic protein (GFAP) marker in central nervous system lesions
Journal Title: Indian Journal of Pathology and Oncology - Year 2017, Vol 4, Issue 3
Abstract
Introduction: The subject of tumours of the nervous system is often looked upon with apprehension by medical practitioners as central nervous system tumours constitute 1-2% of all the neoplasms. Gliomas constitute 38.7% of CNS tumours in which high grade gliomas are 59.5% of patients with systemic malignancies develop brain metastasis during their disease. Glial fibrillary protein is the most frequently used marker in diagnostic neuro-oncology. Positive reaction to GFAP has been demonstrated in astrocytomas, ependymoma and astrocytic cells of mixed gliomas, subependymal giant cell astrocytoma, pleomorphic xanthoastrocytoma, astroblastoma and gliosarcoma. Aim of the study: In the present study the main aim is to differentiate glial tumours from other lesions by morphology and confirmation by using Glial Fibrillary Acidic Protein (GFAP) immunostaining. Results: In the present study glial tumors formed the largest group of cases (44 cases; 41.9%) diagnosed on cytology. They were further divided into low grade and high grade glioma / astrocytoma (33 cases, 31.4%), oligodendroglioma (1 case, 0.95%) and ependymoma (7 cases, 6.6%) based on cytological features. Subsequently, as shown in table IX, the cytohistopathological correlation for glioma / astrocytoma was 91.6%. There were 10 cases which turned out to be oligodendroglioma (4 cases, 11.1%), ependymoma (4 cases, 11.1%) and ganglioglioma (2 cases, 6.0%).
Authors and Affiliations
Geeta W. Mukhiya, Gulshan K. Mukhiya, KK Bansal
Keywords
Related Articles
- EP ID EP315693
- DOI 10.18231/2394-6792.2017.0101
- Views 80
- Downloads 0
Organic causes of abnormal uterine bleeding-A clinico- pathological study based on PALM category of FIGO classification
Background: Abnormal uterine bleeding (AUB) is one of the most common debilitating menstrual problems and has remained one of the most frequent indications for hysterectomy in developing countries. The problem is common...
A diversity of central nervous system tumours at a tertiary care centre-a one year prospective study
Introduction: Central nervous system tumours represent unique heterogenous population of neoplasms which include both Benign and Malignant neoplasms. In India, CNS tumours constitute about 1.9% of all the tumours. These...
Study of p53 gene over expression as a prognostic marker in squamous cell carcinoma of the oral cavity
The present study entitled Study of p53 gene expression as a prognostic marker in squamous cell carcinoma of oral cavity was conducted in the department of pathology SRMSIMS Bareilly 66 cases diagnosed on histopathology...
Value of bronchial wash and brush cytology in addition to histology in the diagnosis of lung cancer
A retrospective study was performed to evaluate the diagnostic yield of lung cancer on biopsy bronchial washings and brushings taken at fibreoptic bronchoscopy Records of 526 patients were analysed and eventually 107 pat...
CD30+ Anaplastic large cell lymphoma with bullous lesions: Good results with steroid + cyclosporine treatment
Anaplastic large cell lymphomas (ALCLs) are type of lymphomas with a strong CD30 positivity. A 38 year old lady presented with tender nodules over forearms and thighs, blisters and ulcerations over forearms, swelling of...