Role of Hepcidin on Response of Erythropoietin Stimulating Agents in Anaemic Advanced Chronic Kidney Disease Patients

Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 10

Abstract

ABSTRACT Introduction: Anaemia contributes significantly to the morbidity and mortality in Chronic Kidney Diseases (CKD). Erythropoietin Stimulating Agents (ESA) have revolutionised the management of the anaemia in CKD patients. However, over 50% of the patients do not reach the target haemoglobin level. Hepcidin which plays important role in iron metabolism and inflammation may be the cause of this hyporesponsiveness to ESA. Aim: The present study was aimed to assess possible relation between hepcidin and erythropoietin therapy with special attention to hyporesponsive anaemia in advanced kidney disease. Materials and Methods: In this cross sectional study, total of 81 clinically stable patients from Department of Medicine and Nephrology, King George’s Medical University, Lucknow of advanced CKD on ESA for past 12 weeks were enrolled. Patients whose haemoglobin rose more than 2 gm/dL or were above 10 gm/dL were classified as responders while below 10 gm/dL were classified as poor responders. Results: In present study, majority 54 patients (66.7%) were poor responders to ESA. We found significant higher level of hepcidin in poor responders (p=0.01) while no significant variation in serum iron, Transferrin Saturation (TSAT) and ferritin. High sensitivity C-Reactive Protein (hsCRP) was markedly elevated with median value 3.13 mg/L and Interquartile Range (IQR) (1.14-13.78) in all patients. Conclusion: Hepcidin may be one of the causes of hyporesponsiveness to ESA due to reticulo-endothelial blockade of iron.

Authors and Affiliations

Satyendra Kumar Sonkar, Anil Kumar, Neeraj Kumar Singh, Gyanendra Kumar Sonkar, Sant Pandey, Vivek Bhosale

Keywords

Related Articles

Biometrics of Pyramidalis Muscle and its Clinical Importance

Introduction: Pyramidalis is classified as a vestigial muscle which is frequently present. It is muscle of the anterior abdominal wall. It is thought to tense the linea alba. It has been used as a surgical landmark, sour...

Impact of a Structured Tuberculosis Awareness Strategy on the Knowledge and Behaviour of the Families in a Slum Area in Chhattisgarh, India

Introduction: Of different methods of disease prevention, health education and awareness programmes can empower people regarding several aspects of disease management and thereby enabling them in accessing the right trea...

Flat Foot in a Random Population and its Impact on Quality of Life and Functionality

Introduction: Flat foot is a common deformity in adults. It is characterized by medial rotation and plantar flexion of the talus, eversion of the calcaneus, collapsed medial arch and abduction of the forefoot. Aim: The a...

An Unusual Presentation of Metanephric Adenofibroma: A Rare Case Report

Metanephric adenofibroma is a rare renal neoplasm with only a few case reports in literature. In majority of cases, it is asymptomatic. However, it may present with haematuria, polycythemia or hypertension. Radiologicall...

Management of Severely Atrophic Mandibular Ridge using Hollow Denture with an Analytical Discussion: A Clinical Case Report

A severely resorbed edentulous mandibular ridge, although fairly common in occurrence, its rehabilitation poses a challenging clinical situation for the prosthodontist. This has implored prosthodontists to seek for ingen...

Download PDF file
  • EP ID EP526692
  • DOI 10.7860/JCDR/2018/36051.12142
  • Views 73
  • Downloads 0

How To Cite

Satyendra Kumar Sonkar, Anil Kumar, Neeraj Kumar Singh, Gyanendra Kumar Sonkar, Sant Pandey, Vivek Bhosale (2018). Role of Hepcidin on Response of Erythropoietin Stimulating Agents in Anaemic Advanced Chronic Kidney Disease Patients. Journal of Clinical and Diagnostic Research, 12(10), 14-16. https://europub.co.uk./articles/-A-526692