Role of Intralesional Measles Mumps Rubella Vaccine in Cutaneous Warts: A Case Control Study
Journal Title: Journal of Chalmeda AnandRao Institute of Medical Sciences - Year 2017, Vol 14, Issue 2
Abstract
Background: Destructive and immunotherapeutic methods are the commonly employed treatment modalities for warts. Intralesional immunotherapy using antigens and vaccines has been shown to be effective in management of cutaneous warts. We here by evaluated the efficacy of Measles Mumps Rubella (MMR) vaccine injection in the treatment of cutaneous warts. Aim: The aim of study was to study the safety and efficacy of intralesional Measles Mumps Rubella (MMR)vaccine in treatment of warts. Materials and Methods: This study was conducted from Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, from January 2017 to December 2017. The study included 50 clinically diagnosed cases of cutaneous warts with single or multiple lesions. They were randomly assigned into two groups (25 in each group). First group included twenty five patients received intralesional MMR vaccine, and second group included twenty five patients received intralesional saline as a control group. Both treatments given into single lesion or into the largest wart in case of multiple lesions at 3 weeks intervals for a maximum of three treatments. Follow up was made every 2 months for 6 months to detect any recurrence. Results: A highly significant difference in therapeutic responses was found in multiple cutaneous warts to MMR vaccine and saline control group. At the end of third visit ( 9 weeks) about 72% patients showed complete response, 16% patients showed partial response in MMR treated patients and no response was seen in 12% of patients. In 12% patients recurrence was observed in MMR vaccine treated group. Conclusion: Intralesional immunotherapy by MMR vaccine in treatment of common warts was effective with good cure rates and safety profile.
Authors and Affiliations
Vontela Rohit, Manasa vadthya, Narendar Gajula, Nishita vumma
Keywords
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