Role of intravenous zoledronic acid in treatment of osteoporosis
Journal Title: Medpulse International Journal of Orthopedics - Year 2018, Vol 8, Issue 1
Abstract
Background: Zoledronic acid is used this to prevent or treat osteoporosis in men and post-menopausal women and patients on glucocorticoids. However, the clinical evidence in the effect of Zoledronic acid on osteoporosis and its complication is conflicting. Aim: To determine the increase in Bone Mineral Density among patients treated with Zoledronic acid using Dual X-Ray Absorbtiometryto track and document improvement. Material and Methods: A total of 30 subjects were recruited by simple random sampling. The baseline BMD of all the participants was measured using DEXA scan. Single dose of Zoledronic acid 5 mg by intravenous infusion is given over at least 15 minutes to all patients. The repeat BMD of all the participants was measured after 6 months of Zoledronic acid infusion to find its effect. Results: The mean BMD of lumbar spine increased significantly from pre-infusion value of 0.79 g/cm2 to post-infusion of 1.32 g/cm2. The T-score also increased from pre-infusion value of -2.367 ± 0.87 to -1.488 ± 0.06 in 6 months following the infusion. The increase is 37.13% higher than pre infusion values. There was a statistically significant improvement in the BMD values 6 months after infusion of Zoledronic acid. Conclusion: Over a short term period, the study concludes that Zoledronic acid has positive benefit in enhancing the T-Score values in osteoporosis and osteoporotic patients.
Authors and Affiliations
Soundararajan K
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- EP ID EP465648
- DOI 10.26611/1020812
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