Role of Low Dose Mifepristone on Uterine Leiomyoma in Reproductive Age Group: A Prospective Study
Journal Title: Indian Journal of Obstetrics and Gynecology - Year 2018, Vol 6, Issue 4
Abstract
Aim: To study the effect of low dose mifepristone on the leiomyoma volume reduction, leiomyoma-related symptoms and endocrinal profile in patients with symptomatic leiomyoma. Setting: Tertiary care hospital Material and Methods: Sixty-two patients with symptomatic uterine leiomyoma were recruited and distributed to receive 10 mg mifepristone (Group 1) and placebo capsule containing 10 mg lactose (Group 2) OD for 3 months. Baseline leiomyoma-related symptoms and leiomyoma volume was recorded, followed by monthly assessment for three months. Baseline hormonal profile was done and repeated at the end of therapy. Main outcome measure (s): The reduction in the uterine leiomyoma volume, effect of mifepristone on the leiomyoma-related symptoms and the hormonal levels. Result (s): There was a significant percentual decrease (p = 0.000) in the total leiomyoma volume in the mifepristone-treated group, -58.36±8.92% (mean ±S.D), compared with the control group, 0%. Mifepristone treatment significantly reduced the bleeding days (p = 0.000) by causing amenorrhea in all the patients (100%). There was a significant improvement in the leiomyoma-related symptoms and the hormonal levels remained unchanged. Conclusion: Mifepristone may offer an effective conservative treatment option for women with symptomatic uterine leiomyoma and the associated pronounced uterovaginal bleeding. It is efficacious in reducing leiomyoma volume and leiomyoma-related symptoms of menorrhagia and dysmenorrhoea.
Authors and Affiliations
Varun Neha
Keywords
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- EP ID EP549908
- DOI 10.21088/ijog.2321.1636.6418.6
- Views 65
- Downloads 0
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