Role of molecular examinations in qualification to first line treatment with erlotinib in NSCLC patients based on EURTAC study results
Journal Title: OncoReview - Year 2013, Vol 3, Issue 1
Abstract
Between 2010–2011 the first EGFR thyrosine kinase inhibitor (EGFR TKI) – gefitinib, was registered in many countries in I line of treatment in patients with advanced and locally advanced non-small cell lung cancer (NSCLC), among whom EGFR gene mutations have been detected. It was also found that the presence of these mutations is crucial for the effectiveness of EGFR TKI – erlotinib, used so far mainly in monotherapy in II line in NSCLC patients, with unknown EGFR gene status. Studies of these two drugs concerned mostly Asian NSCLC populations, where EGFR gene mutations occurrence is much higher than in Caucasian populations. The EURTAC study, and a study by Rosell et al. previous to it, were the first ones that confirmed the effectiveness of erlotinib in adenocarcinoma patients of Caucasian origin, who carried EGFR gene mutations:exon 19 deletions or L858R substitution in exon 21 of this gene. The innovative nature of this study is to attempt to detect EGFR gene mutations in free circulating DNA in peripheral blood, which could broaden the possibility of advanced NSCLC patients qualification to EGFR TKI treatment. The EURTAC study also has its weaknesses, among which disqualification of patients with other forms of non-squamous NSCLC (e.g. large cell carcinoma patients, who also might be carriers of EGFR gene mutations) and patients with rare EGFR gene mutations, are the most distinct.
Authors and Affiliations
Paweł Krawczyk
Keywords
Related Articles
- EP ID EP53200
- DOI -
- Views 240
- Downloads 0
Pleural effusion in patient with chronic myeloid leukemia treated with dasatinib - a case report
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm with inherence of a cytogenetic abnormalities in the shape of translocation of gene ABL from chromosome 9 to chromosome 22, t(9,22)(q34;q11). Current standa...
PTEN – clinical significance in colorectal cancer
Phosphatase and tensin homolog deleted on chromosome ten (PTEN ) is a human suppressor gene. Its protein product is a bispecific phosphatase playing the complex role in the cell cycle regulating processes and apoptosis b...
Everolimus-induced interstitial lung disease in patient with metastatic renal cell carcinoma – case report and literature review
We present a case of a 70-year-old man with metastatic renal cell carcinoma treated with second-line everolimus after rapid progression on first-line tyrosine kinase inhibitor, in whom a side effect of the therapy occurr...
Nefrotoksyczność leków stosowanych w chemioterapii nowotworów
Rozwój onkologii klinicznej oraz coraz częstsza zapadalność na nowotwory powodują szybkie zwiększanie się grupy chorych leczonych chemioterapeutykami. Stosowanie tych leków oprócz korzyści niesie ze sobą również ryzyko w...
Everolimus in clinical practice. Review of German non-interventional study of everolimus in metastatic renal cell cancer after failure of initial tyrosine kinase inhibitor therapy
Everolimus is a standard for treatment of anti-vascular endothelial growth factor (VEGF)-refractory patients with metastatic renal cell carcinoma (mRCC). A German study documented mRCC patient treated everolimus from 79...