Role of MR spectroscopy in evaluation of patients with temporal lobe epilepsy
Journal Title: Medpulse International Journal of Radiology - Year 2018, Vol 6, Issue 2
Abstract
Background: Temporal lobe epilepsy is the most frequent cause of focal and refractory seizures. MRS pectroscopy detects abnormalities that are invisible to conventional MRI. It has demonstrated consistent metabolic abnormalities in temporal lobe epilepsy. Aim: To evaluate the role of MR spectroscopy in evaluation of patients with temporal lobe epilepsy. Material and Methods: A total of 15 patients of either sex with temporal lobe epilepsy were selected for the study. MR imaging of the temporal lobes was performed on a clinical 1.5 Tesla MRI system employing standardized epilepsy protocol. The temporal lobes and bilateral hippocampus were evaluated by oblique coronal T2 weighted FSE and T1 weighted SPGR sequences. Subsequently multivoxel MR spectroscopy was performed with 10mm voxel positioned over the temporal lobe including bilateral hippocampus. Results: Twelve of the 15 patients with temporal lobe epilepsy had normal MR scans. The mean NAA value of right and left hippocampus of TLE patients were minimally reduced when compared to that of the reference mean. The mean Choline value of right hippocampus of was minimally increased and that of left hippocampus was significantly increased when compared to reference mean value of the right and left hippocampus respectively. Conclusion: Multi Voxel Magnetic Resonance Spectroscopy of bilateral hippocampus can be used as an important, additional and supplementary diagnostic tool in the assessment of TLE.
Authors and Affiliations
Arunan Murali, T Bhasker Raj, Venkata Sai, Sheila Elangovan, J Saranya
Keywords
Related Articles
- EP ID EP533427
- DOI 10.26611/1013626
- Views 108
- Downloads 0
Etiological features of seizures in paediatric patients: A hospital based magnetic resonance imaging study
Background: Children with epilepsy differ from adults not only in the clinical manifestations of their seizures, but also in etiologies. Primary generalized epilepsy is considered to be genetic in etiology, whereas most...
Differential diagnosis of breast lesions by ultrasonography and its correlation with mammography
Background: Breast disease in women encompasses a spectrum of both benign and malignant disorders. High resolutions sonography is an adjunct used in detecting lesions in dense breast and supplementary assessment of breas...
Diagnostic value of musculoskeletal USG in patients with rheumatoid arthritis of wrist at a tertiary care center
Background: Musculoskeletal ultrasound may be used to assist needle positioning to facilitate invasive rheumatological procedures such as aspiration of fluid, drainage of abscess, tissue biopsy and local injection of the...
A study of diagnostic accuracy of MRI in the contrast-enhanced magnetic resonance imaging in diagnosis of meningitis correlated with CSF analysis at tertiary health care centre
Background: Meningitis is a significant health problem worldwide and can be a life-threatening emergency if not suspected, appropriately diagnosed, and managed expeditiously Aims and Objective: To Study diagnostic accura...
A study on fetal umbilical, MCA doppler parameters in borderline AFI and oligohydramnios
The incidence of oligohydramnios in Indian population is 4-5% and has many causes, the most common being IUGR. The incidence of IUGR varies from region to region and even in the same region, it varies in different sub po...