Role of Nifidipine in Preterm Labour - A Prospective Study
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 3
Abstract
Background: Preterm labour and delivery remains a major cause of perinatal morbidity and mortality in the developing world. Numerous drugs and interventions have been used to prevent and inhibit the preterm labour but none have been found to be completely effective with the choice being further limited by their side effects profile. Tocolysis, the pharmacological inhibition of uterine contractions, is currently the treatment for preventing PTL. Objectives: To assess the efficacy and pregnancy outcome of nifedipine in the treatment of preterm labour and to evaluate the maternal and fetal adverse effects associated with nifedipine. Methods: This is a prospective randomized study, 100 antenatal cases with 28 to below 37 weeks of gestation with painful intermittent uterine contractions associated with cervical changes were considered for the study. They were given oral nifedipine and monitored for cessation of uterine contractions. Maternal and fetal side effects were also noted. The main outcomes include prolongation of pregnancy, maternal side effects and neonatal outcome. Results: The mean prolongation of pregnancy was 30.41 days. Success rate with Nifedipine was found to be 92.8%. Significant maternal side effects such as hypotension and tachycardia were seen only in 2 patients. Facial flushing was the most common side effect observed in the study group.15% of the patients exhibited fetal tachycardia. 90% of the neonates had an apgar score of above 7 at 5 minutes with no incidence of neonatal morality or morbidity. Conclusions: Nifedipine is a cost - effective, safe tocolytic agent with minimal adverse effects
Authors and Affiliations
Dr S . V. Nachiketha
Keywords
Related Articles
- EP ID EP279038
- DOI -
- Views 67
- Downloads 0
Undernutrition Among Under Five Children Of Rural and Hilly areas of Khag, Kashmir, India: A Community Based Cross-Sectional Study
Background: Undernutrition among under five is one of the greatest public health problems in developing countries particularly in those residing in rural and hilly areas. This study aimed to assess the prevalence of unde...
Nipah Virus: A Hidden and Continuous Threat to Humankind
Nipah virus, a member of family Paramyxoviridae, genus Henipavirus causes acute and severe respiratory illness and encephalitis in humans. The primary source of infection is through infected pigs and bats. Virus was firs...
Application of Magnetic Resonance Spectroscopy in the Differentiation of High-Grade Brain Neoplasm and Inflammatory Brain Lesions
This study aims at evaluating the application of magnetic resonance spectroscopy (MRS) in the differential diagnosis of brain tumors and inflammatory brain lesions. The examinations of 81 individuals, who performed brain...
A cross-sectional study is conducted on Bangabandhu Sheikh Mujib Medical University (BSMMU) for identify demographic characteristics and symptoms of epilepsy related headache
Introduction: Epilepsy and primary headache disorders affect individuals of all ages worldwide. Headache and epilepsy are two relatively common neurological disorders and their association is still a matter of debate. Ob...
Role of Anti-Oxidant Vitamin C in Post Operative Pain Relief in Foot and Ankle Surgery
Aims and Objectives: The primary objective of the study is to assess the efficacy of Anti-oxidant Vitamin C in postoperative pain relief in foot and ankle surgery. Materials and Methods: This is a Randomized Comparative...