Role of nuclear factor kappaB in the central nervous system.
Journal Title: Pharmacological Reports - Year 2007, Vol 59, Issue 1
Abstract
The aim of this review was to assemble current literature data on nuclear factor kappa B (NF-kappaB). Many authors believe that NF-kappaB, a transcription factor, has essential influence on the regulation of numerous genes in the organism. In this review, we have focused on the role of NF-kappaB and its target genes in the central nervous system functioning. Unfortunately, the contribution of NF-kappaB to neuroprotection or to neurodegeneration is not clear, yet. Therefore, its exact role in these processes and potential applications in pharmacology are still to be determined.
Authors and Affiliations
Robert Małek, Kinga Borowicz, Małgorzata Jargiełło, Stanisław J Czuczwar
Keywords
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