Role of Nuclear Grooves in Cytological Diagnosis of Papillary Carcinoma Thyroid
Journal Title: Saudi Journal of Pathology and Microbiology - Year 2018, Vol 3, Issue 10
Abstract
It is well known that nuclear grooves play a major role in the diagnosis of papillary carcinoma thyroid. Also grooves are found in many non- neoplastic lesions of thyroid. To calculate the percentage of nuclear grooves in histopathologically proven cases of papillary carcinoma and non –neoplastic lesions (hashimoto’s thyroiditis and colloid goiter). This retrospective study was carried out by reviewing the data and cytology smears of 21 histopathologically confirmed cases of papillary carcinoma thyroid and 10 cases each of hashimoto’s thyoiditis and colloid goitre. The percentage of nuclear grooves was calculated in oil immersion by counting 100 to 500 cells depending on the cellularity. The percentage of nuclear grooving ranged from 15% to 85% in the papillary carcinoma cases. Greater than 20% nuclear grooves were observed in 19(90.4%) of the cases. Nuclear crowding and overlapping, pale chromatin, nuclear grooves, nuclear enlargement and prominent nucleoli were seen in all (100%) the cases. Intranuclear cytoplasmic pseudoinclusions were seen in only 5(23.8%) of the cases. Histiocytes, metaplastic cells and multinucleated giant cells were seen in 12(57.1%), 10(47.6%) and 6(28.5%) of the cases. The percentage of nuclear grooves in non neoplastic cases overall observed was <10%. The sensitivity and specificity of grooves for PCT at >=20% were 90.5% and 100% respectively. Whenever in doubt, a diagnosis of papillary carcinoma can be offered confidently by this semiquantitative approach for grooves in combination with other features.
Authors and Affiliations
Dr. Bhat Archana S, Dr. Varma Lisa, Dr Fernandes Hilda, Dr C S Jayaprakash
Keywords
Related Articles
- EP ID EP484253
- DOI -
- Views 83
- Downloads 0
Monoclonal gammopathy in systemic lupus: a case report
Abstract: The occurrence of monoclonal gammopathy of undeterminate significance (MGUS) in an autoimmune disease such as systemic lupus is not common but it is not as rare as the occurrence of a malignant disease such as...
Antimicrobial Activity of solvent Extracts of Selected Red Sea Macroalgae against Some Pathogenic Microorganisms
Abstract:This study was carried out to evaluate the antimicrobial activity of hexane, chloroform, ethyl acetate and water extracts of six marine macroalgaebelonging to different families namely green algae (Chlorophyceae...
Isolated Spinal Langerhans Cell Histiocytosisis a Close Mimic of Pott’s Disease in the Tropics
Abstract:Spinal tuberculosis (pott’s disease) is a common manifestation of extrapulmonary tuberculosis. Spinal langerhans cell histiocytois is also a granulomatous condition which can resemble pott’s disease in many aspe...
Isolation and Identification of some Oral Microorganisms from Healthy Sudanese Smokers and Oral Cancer Patients
Abstract: This study was conducted to identify any possible association between the different microorganisms within oral cavity of smokers and oral cancer patients. Isolates were collected from 30 volunteers; smokers and...
Dengue Virus Antibodies in Patients Presenting with Pyrexia attending Jos University Teaching Hospital, Jos, Nigeria
Abstract:Dengue virus (DENV) is the most common mosquito-transmitted human flavivirus worldwide, and it is well-established that DENV and Zika virus are closely related, resulting in substantial antigenic overlap. The i...