Role of radiotherapy in Masaoka stage II and III thymomas – single center experience
Journal Title: Ege Tıp Dergisi - Year 2019, Vol 58, Issue 3
Abstract
Aim: Thymomas are rare neoplasms. Complete surgical resection is the cornerstone of the treatment. The role of adjuvant radiotherapy (RT) in Masaoka stage II disease is controversial, but in more advanced stages and the role of radical RT in inoperable cases are clear. This study is conducted to evaluate local control, relapse free survival and overall survival rates in Masaoka stage II and III thymoma patients after adjuvant or radical RT. Materials and Methods: The medical records of thymoma patients who were treated and completed their RT course between January 2010 and August 2016 in a single center were evaluated retrospectively. Results: Twenty-two patients were available for analysis. Treatment planning was adjuvant in 18 patients and radical in 5 patients. Median age at diagnosis was 59 (50-62). Type of resection was R0 in all cases. The adjuvant RT dose was 50 Gy; radical RT dose was 60-66 Gy. The most common acute toxicity was grade 1 pneumonitis which was reported in 9 patients (39%). Grade 2 acute pneumonitis was experienced by 3 patients (13%), grade 2 acute esophagitis was experienced by 2 patients (9%). One patient had late grade 3 esophageal toxicity. Follow-up time ranged from 6 to 99 months, median 18 months, local control rate was 100%, relapse free survival (RFS) was 96%, cancer specific survival was 96%, 2 years overall survival (OS) was 83%. Conclusion: Although our results seem to be in concordance with the literature, longer follow-up is needed to be able to make a conclusion in terms of LC, RFS and OS, since thymoma has an indolent course with low relapse rate and long RFS
Authors and Affiliations
esra korkmaz kıraklı, Sevilay erdem, mediha tülin bozkurt, Hasan Yılmaz
Keywords
Related Articles
- EP ID EP637363
- DOI 10.19161/etd.468605
- Views 90
- Downloads 0
Asterion yerleşiminin posterolateral intrakraniyal girişimler açısından morfometrik değerlendirilmesi
Amaç: Beyin cerrahisinde, fossa cranii posterior’a ulaşmayı gerektiren cerrahi girişimlerde, cranium’a giriş noktası yüzeyel anatomik belirgin noktaların yardımıyla belirlenir. Asterion’un, cranium’un posteroateralinde k...
Multidisciplinary approach for complicated Fournier gangrene
Fournier gangrene is an infectious disease originates from perineal and gluteal region spreading throughout the fascia. Life threatining results can be seen due to insufficient debridation or delay in treatment. A 23-yea...
Reproductive outcomes after hysteroscopic septoplasty and comparison of different surgical techniques: A retrospective cohort study
Aim: Uterine septum affects a large proportion of women, especially patients with recurrent abortion. Hysteroscopic septoplasty is a novel and minimally invasive method for its treatment. Pregnancy rates after hysterosco...
Biyolojik ajanların pulmoner komplikasyonları
İnflamatuvar romatolojik hastalıklarda biyolojik ajanların kullanımı ile ilgili veri sayısı artmaktadır. Son zamanlarda, biyolojik ajanlarla ilişkili non-enfeksiyöz komplikasyonlar arasında en sık granülomatöz hastalık v...
Antiphospholipid antibody associated adrenal hemorrhage causing acute adrenal insufficiency
Arterial or venous thrombosis can be seen in the presence of antiphospholipid antibody. Various pathogenetic mechanisms are put forward in case of antiphospholipid syndrome. Herein a case of 62-year-old male patient who...