Role of Serum Leptin and its association with Malondialdehyde in Type 2 Diabetic Patients
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 1
Abstract
Background: Leptin is a hormone produced by adipose tissue that regulates a number of physiological processes and behaviors including appetite, body weight, neuroendocrine functions and glycaemia. These effects are mediated via actions on leptin receptors (LepRs) expressed by neurons in the central nervous system (CNS). Aim: The aim of this study was to evaluate the significance of leptin levels in T2DM patients compared with controls and to determine the association of leptin with malondialdehyde (MDA) Materials and methods: Thirty T2DM patients with the age group of 35 to 50 years were selected for this study and 30 healthy age matched subjects were selected as a control group. Serum leptin was assessed by ELISA, malondialdehyde (MDA) was assessed by Thiobarbituric Acid Reactive Substances (TBARS) method and routine investigations were done by ERBA EM-360 fully automated analyzer. Results: The mean level of serum leptin was significantly increased in T2DM patients compared with controls. Serum leptin levels were positively correlated with FPG, PPG, HbA1c, Homeostasis model assessment of insulin resistance (HOMA-IR), malondialdehyde, Cholesterol, TGL, LDL, BMI and negatively correlated with HDL. Conclusion: Leptin might be useful diagnostic marker for the severity of inflammation, chronicity of the disease and vascular complications.
Authors and Affiliations
Santhi. T, Keerthana. B, Anil Kumar. T, Balu Mahendran. K
Keywords
Related Articles
- EP ID EP588805
- DOI 10.9790/0853-1601034346
- Views 63
- Downloads 0
A Study of Calcification of Costal Cartilages (1st To 7th) In Different Age Groups and Its Effect on Chest Expansion in Both Male and Female
Background: Costal cartilage calcification progresses with age and shows differences in sexual preponderance. Studies have been done on these parameters. But, few studies have been done encompassing both age, sex and eff...
Pre-Admission Factors Influencing Neonatal Mortality
Background: Every year 70% of neonatal deaths take place because simple yet effective interventions do not reach the needy. Objective: To study the pre-admission factors affecting neonatal outcome. Materials And Methods:...
Applying Operations Research Techniques to Minimize Delays in Hospital Operations
Operations research (OR) focus on the application of analytical methods to facilitate better decisionmaking. Regardless of its convenience and multiplication of papers in the scholarly writing, there are as yet significa...
Study on fracture fixation in comorbid conditions
There are many co morbid conditions which exist before a fracture is sustained and developed or identified during the evaluation for fitness to undergo surgery. The study is done with 83 patients who are diagnosed as hav...
A Study on Surgical Site Infections in Emergency Non-Traumatic Abdominal Operations
Background: Surgical site infection (SSI) has always been a major complication of surgery and trauma and has been documented for 4000-5000 years. Surgical site infections are the third most common hospital associated inf...