ROLE OF SYSTEMIC ANTIBIOTICS AND TOPICAL ANTISEPTICS IN RECURRENT ATOPIC DERMATITIS NOT RESPONDING TO TOPICAL IMMUNOSUPPRESSIVES
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 90
Abstract
BACKGROUND Atopic dermatitis (AD) is a highly pruritic inflammatory skin disease that results from complex interaction between genetic susceptibility genes and environmental factors resulting in defective skin barrier, defects in innate immune system, heightened immunologic response to allergens and microbial antigens. The objective of this study is to evaluate the response of systemic antibiotics and topical antiseptics in patients of recurrent atopic dermatitis who were recalcitrant to topical immunosuppressives. MATERIALS AND METHODS 100 children attending Dermatology Clinic with recurrent Atopic Dermatitis, not responding to topical immunosuppressives were enrolled in the prospective study. They were treated for 5 days with Systemic Antibiotics, Systemic Antihistamine and Topical Antiseptic. They were followed up on 5th, 7th and 10th day and evaluated using SCORAD scoring. RESULTS Out of 100 children, lesions of 11 patients resolved after the use of systemic antistaphylococcal antibiotics, topical antiseptics and systemic antihistaminics; 84 patients showed remission after using topical steroids of higher potency combined with systemic antibiotics and topical antiseptics. Only 5 patients on systemic antibiotics and topical antiseptics required systemic steroids. SCORAD score was very useful in evaluating the patient’s condition, their response to treatment and decision to start immunosuppressives. CONCLUSION As systemic antibiotics and topical antiseptics were able to reduce erythema and oozing of atopic patches, it shows that microbial colonisation is an important factor in the precipitation of AD. As our study showed optimum results, patients of recurrent AD recalcitrant to topical immunosuppressives should be initially treated with systemic antibiotics, topical antiseptics and systemic antihistaminics. Based on the SCORAD score and efficacy of treatment, the immunosuppressives can be added.
Authors and Affiliations
Parag Sharma
Keywords
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- EP ID EP278259
- DOI 10.14260/jemds/2017/1383
- Views 89
- Downloads 0
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