Role of Therapeutic plasma exchange in various medical disorders: An Experience from SMS hospital, Jaipur, Rajasthan.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2019, Vol 4, Issue 1
Abstract
Background: Therapeutic plasma exchange (TPE) is the treatment of choice in many neurological, nephrological, hematological and various other disorders.TPE is used either standalone therapy or in conjunction with other modalities of treatment according to their category of indications. Even though it is safe in experienced hands, there is a major concern about its safety among physicians. Objectives: To analyze our experience with patients who underwent TPE for various diseases admitted in SMS hospital Jaipur. Materials and Methods: A Retrospective study of Therapeutic plasma exchange procedures done during a period of 3 years, from Jan 2014 to Dec 2016 by Dept. of Immunohematology and Transfusion medicine in SMS hospital Jaipur. TPE was performed by HAEMONITICS MCS+. Indications, clinical results and technical factors are discussed. Results: The main indication for TPE were Neurological disorders Guillain-Barré syndrome 13,(25.4%), Myasthenia Gravis, 10,( 19.6%), Neuromyelitis optica 11,(21.5%),Chronic Inflammatory Demyelinating Polyneuropathy 2, (3.9%), Longitudinally Extensive Transverse Myelitis 2,(3.9%), TPE was performed for 12 cases of for Antibody mediated transplant rejection (23.5%) and 1 case of Thrombotic Thrombocytopenic Purpura (1.96%) . Age of patients ranged from 13-65 years. Most common age group of patient were (20-40 year).The most common complications were mild allergic reactions (7.8%), paresthesia and/or cramps (3.9% ), and hypotension(3.9%) .There was no procedure related mortality. Conclusion: The analysis of 51 patients and 187 procedures of TPE done by our department shows that the procedure is safe, with only minimal procedure related complications and no mortality.
Authors and Affiliations
Ashok Pal
Keywords
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