Roxithromycin as Anti-Inflammatory Drug Improves Clinical Outcomes in Adult Patients with Bronchiectasis: A Double- Blinded Randomized, Placebo-Controlled Pilot Clinical Trial
Journal Title: Journal of Health Science and Medical Research (JHSMR) - Year 2019, Vol 37, Issue 3
Abstract
Objective: Macrolides are anti-inflammatory agents that have been reported to improve symptoms in bronchiectasis. The objectives of this study were roxithromycin 300 milligrams (mg) once daily for 8 weeks in patients with bronchiectasis improves the symptom scores as the primary outcome, and the pulmonary function tests and quality of life as the secondary outcomes. Material and Methods: This was a randomized double-blinded placebo-controlled trial of roxithromycin or placebo once daily for 8 weeks in patients with bronchiectasis. Symptom scores, pulmonary function tests, St. George’s Respiratory Questionnaire (SGRQ), and sputum culture were done at each visit. Results: Twenty-eight bronchiectasis patients with a mean age of 56 years participated in this study. Fourteen patients were randomized to receive either roxithromycin 300 mg or placebo once daily. Roxithromycin was shown to improve symptom scores (mean difference of symptom scores=–1.66, p-value=0.005) compared with placebo (mean difference of symptom scores=-0.06, p-value=0.94). Quality of life assessed by the SGRQ, significantly improved in the roxithromycin group (p-value=0.012) but not in the placebo group (p-value=0.84). Pulmonary function tests (forced expiratory volume in one second, forced vital capacity, and diffusing lung capacity of the lung for carbon monoxide) did not improve in either group. None of the patients in the roxithromycin group reported any adverse effects. Conclusion: Roxithromycin once daily showed benefits in clinical outcomes such as symptoms and quality of life. Larger studies of the effects of roxithromycin in bronchiectasis with longer follow-up should be done.
Authors and Affiliations
Siwasak Juthong, Sarayuth Eiamsa-ard
Keywords
Related Articles
- EP ID EP678076
- DOI http://dx.doi.org/10.31584/jhsmr.201956
- Views 208
- Downloads 0
Outcome of Transient Hypogastric Artery Balloon Occlusion with Cesarean Hysterectomy in Abnormal Adherent Placenta: Case Series
Objective: To evaluate the outcome of pregnant women with abnormal placentation who underwent transient hypogastric artery balloon occlusion with cesarean hysterectomy. Material and Methods: Descriptive retrospective st...
Ergonomic Recommendation of Suitable Toilet Seat Height for Older Thai People
Objective: This study aimed to determine the main factors affecting older people as they rise from a toilet seat and to identify the suitable toilet seat height for this population. Material and Methods: Data from 342 o...
Evidence-Based Neonatal Care
Aging societies are developing around the world while the number of newborns is decreasing. The best neonatal care is a crucial issue since prematurity is surging along with high mortality and morbidity in developing cou...
Prevalence of Antibiotic Resistance in Escherichia coli from the Fecal Flora of Humans in a Rural Area of Songkhla Province
Objective: To determine the prevalence of antibiotic resistance in fecal Escherichia coli (E. coli ) isolated from humans in a rural area of Songkhla province. Meterial and Methods: E. coli strains were isolated from th...
Current Management of Difficult Central Venous Access in Pediatric Patients
The central venous catheter (CVC) has become an integral part of various long term parenteral therapies including chemotherapy and parenteral nutrition. In pediatric patients with a long term CVC, multiple repeated acces...