RP – HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE ANALYSIS OF TENOFOVUIR IN PHARMACETICAL DOSAGE FORMS
Journal Title: Journal of Atoms and Molecules - Year 2011, Vol 1, Issue 1
Abstract
A simple, selective, linear, precise and accurate RP-HPLC method was developed and validated for rapid assay of TENOFOVUIR in tablet dosage form. Isocratic elution at a flow rate of 1ml min-1 was employed on a symmetry C18 column at ambient temperature. The mobile phase consisted of Methanol:Acetonitrile:OPA 85:10:05 (v/v/v). The UV detection wavelength was at 260nm.Linearity was observed in concentration range of 5-35ppm. The retention time for TENOFOVUIR was 2.3 min. The method was validated as per the ICH guidelines. The proposed method can be successfully applied for the estimation of TENOFOVUIR in pharmaceutical dosage forms.
Authors and Affiliations
B Syam Sunder, Edla Subhashini
Keywords
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- EP ID EP366863
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