RP-HPLC method development and validation of valizodone in pure and tablet dosage form
Journal Title: International Journal of Novel Trends in Pharmaceutical Sciences - Year 2015, Vol 5, Issue 2
Abstract
A simple, precise, rapid, accurate and economic reverse phase high performance liquid chromatographic method has been developed for the estimation ofValizodone in tablet dosage form. The separation was achieved by using octadecylsilane column (C 18 ) and acetonitrile : water in proportion of 60:40 v/v as mobile phase, at a flow rate of 1.0 ml/min. The detection was carried out at 240 nm. The retention time of Valizodone was found to be 4.3 min. The limit of detection and limit of quantitation were found to be 0.11 μg/ml and 0.33 μg/ml respectively. The accuracy and reliability of the proposed method was carried out by evaluating various validation parameters like linearity, precision, accuracy and specificity according to ICH guidelines.
Authors and Affiliations
Thangabalan B , Lakshmi Narusu R , SyedaliFathima SK , ManoharBabu S
Keywords
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