RP-HPLC method development for the estimation of Levocetirizine and Phenylephrine hydrochloride in combined dosage form
Journal Title: International Journal of Pharmaceutical and Medicinal Reserach - Year 2013, Vol 1, Issue 2
Abstract
A rapid, accurate RP-HPLC method was developed for the simultaneous estimation of Levocetirizine and phenylephrine hydrochloride in combined dosage form. The HPLC separation was achieved on column Luna 5u C18 (20mm X 4mm) using mobile phase of methanol: Pot. Dihydrogen Phosphate Buffer (pH 6.0), (70:30) .The UV detection was performed at 251nm with flow rate of 1.0 mL/min. The retention time of Levocetirizine and Phenylephrine hydrochloride was found to be 8.42 min and 2.70 min with mean recovery 100.64 & 100.40% respectively. The proposed method was found useful in the routinely quantification of both drugs in combined dosage form.
Authors and Affiliations
Brij Bhushan, Uttam Singh Baghel, Ramandeep Singh, Yogesh Kumar
Keywords
Related Articles
- EP ID EP31456
- DOI -
- Views 406
- Downloads 2
Do ‘Patient Management Problems (PMP)’ act as ‘Motivators’ in Internal Assessment examinations?
Context: Problem based learning when used with adult learners stimulates deep learning. Internal motivators are essential as envisaged in principles of Adult learning .In educational spiral, the Internal assessment (fo...
Prevalence and determinants of anaemia among University students living in public hostels, Khartoum state, Sudan
Introduction: Anaemia is a major world health problem and still remains widespread. According to W.H.O, around the world 1.3 – 2.15 billion people are iron deficiency anaemic and more than 90% are living in the developin...
Pioneering and Encouraging Approach Mucoadhesive Drug Delivery System
A Propitious Novel Drug delivery method, Mucoadhesive drug delivery system considerably increase dosage form residence time, furthermore augmenting the affinity with the tissue and localizing the drug in a specific regio...
Fatigue in the Ghanaian Nurse and its impact on patient care
Fatigue is something every person has experienced. It is a natural part of the daily cycle of life. Fatigue among health professionals is becoming a topic of interest among researchers because of its detrimental effect i...
Glibenclamide fabricated transdermal wafers for therapeutic sustained delivery systems
Transdermal wafers of the Glibenclamide (GBE) were developed employing Ethyl cellulose (EC) and Hydroxypropyl methylcellulose (HPMC), Ethyl cellulose and Polyvinyl pyrrolidone (PVP) as a film former. The effect of bina...