Rutyna : budowa, właściwości
Journal Title: Wiadomości Chemiczne - Year 2016, Vol 70, Issue 7
Abstract
Flavonoids commonly can be found in plants. They protect them against various microorganisms or insects [1]. Flavonoids demonstrate not only antioxidant properties, but also prevent the development of cancer [2]. This is attributed to their ability to induce apoptosis of tumor cells. The structure of this type of compound is based mainly on the flavone skeleton with the keto group in position 4 (Fig. 2). The difference in structure of flavonoids consists mainly in the number and nature of the substituents. Flavonoid compounds have a 15-carbon atoms skeleton, consisting of two aromatic rings (A and B) connected to 3 carbon atoms, by oxygen contained within the heterocyclic ring C (Fig. 2) [5]. Structural difference of the pyranose ring C and position of the phenyl ring B are the basis for the division flavonoids into seven groups (Fig. 3) [6]. In recent years a number of work focused on the study of flavonoids complexes with ions of copper(II) or iron(II) were published [20–22]. One of the most important flavonoids is rutoside, which has a number of important biological activities. One of the most important function of this compound is inhibition hyaluronidase activity by reducing the permeation and improveing the flexibility of blood vessels. It is used to treat diseases such as diabetic retinopathy, inflammation of the mucous membranes of the nose, atherosclerotic diseases or disorders of the venous circulation. Rutoside forms a relatively stable complex with ions of iron(II) or calcium(II) as well as nickel(II) and especially with copper(II). This type of complex protect from rapid degradation/oxidation of L-ascorbic acid [14, 15]. In 2011, Sak-Bosnar and colleagues proposed the structure of rutoside complex with ions of copper (II) (Fig. 9) [20]. In the same year was published work suggesting that a key role in this type of mechanism play hydroxyl group at the 3 ‚carbon atom, which becomes a „carrier” of the electron/radical (Fig. 5) [19].
Authors and Affiliations
Justyna Samaszko-Fiertek, Piotr Roguszczak, Barbara Dmochowska, Rafał Ślusarz, Janusz Madaj
Keywords
Related Articles
- EP ID EP585042
- DOI -
- Views 148
- Downloads 0
Znaczenie mikroporowatych materiałów metaloorganicznych (MOF ) dla potrzeb magazynowania wodoru
Currently, the metal-organic frameworks (MOF s) are considered among the most promising materials for hydrogen storage. In this paper, the properties of MOF s that are particularly important for application purposes are...
Skręty zwrotne w peptydach i białkach. Mimetyki skrętów zwrotnych. Część 1
The secondary structure of the proteins can be divided into α-helix, βsheet and reverse turns. A reverse turn is defined as a site where a polypeptide chain reverses its overall direction. It leads the chain to fold back...
Izolacja i identyfikacja naturalnych substancji barwiących obecnych w próbkach farb artystycznych i tkaninach pochodzenia historycznego
Natural organic dyes are group of substances that belong to various types of chemical compounds. The most commonly used in paintings and dyeing textiles were naturally occurring dyestuffs from group of anthraquinones, fl...
Wybrane Metody syntezy 2-amino-1H-benzimidazolu
2-Amino-1H-benzimidazoles have attracted much attention due to their varied biological activities toward numerous diseases. 2-Amino-1H-benzimidazole core structures can be found in commercial drugs such as astemizole, mi...
Zastosowania biologiczne tetrazoli i ich pochodnych
Due to the wide range of applications of tetrazoles, in recent years the number of publications and patents describing the synthesis, structural and physicochemical studies of compounds that contain tetrazole fragments i...