Safety evaluation of petroleum ether, acetone, and hydroalcoholic extracts of Holoptelea integrifolia by oral administration in Wistar rats
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2015, Vol 8, Issue 2
Abstract
 Objective: There are no reports on safety information of Holoptelea integrifolia (Roxb.) Planch. bark extracts by oral administration for long duration.This study is planned to add information on the safety margin of H. integrifolia.Methods: Acute oral toxicity study was carried out in the consideration of OECD guideline 425. Animals were observed for mortality, morbidity,behavior and toxic symptoms for 14 consecutive days. Sub-acute toxicity was planned by employing the OECD guideline 407. Dose 50, 100and 200 mg/kg of the extracts were administered orally, daily for 28 consecutive days. Animals were observed for toxicity sign, morbidity andmortality. Body weight, relative organ weight, biochemical, hematological parameters and histopathology of vital organs like liver and kidneywere evaluated.Results: In the acute oral toxicity study, all the extracts were found to be safe at 1000 mg/kg. However, out of three extracts, petroleum ether extractof the plant showed mild damage to liver and kidney in sub-acute toxicity studies.Conclusion: Hydroalcoholic extract of H. integrifolia is found to be safe, compared to the acetone and petroleum ether extracts for the long-term use.Keywords: Holoptelea integrifolia, Bark, Acute toxicity, Chronic toxicity
Authors and Affiliations
Dushyant Kumar, P A Patil, Harsha V Hegde, S Roy, S D Kholkute
Keywords
Related Articles
- EP ID EP605669
- DOI -
- Views 90
- Downloads 0
AN OVERVIEW OF COLORECTAL CANCER: IMPLICATION OF TWO MEDICINAL PLANTS IN THEIR TREATMENT
Nowadays, cancer is one of the most common diseases in humans. Among all types, colorectal cancer (CRC) is one of the most serious types diagnosed in men after lung and prostate cancer while in women it occupies the seco...
P-SELECTIN GLYCOPROTEIN LIGAND-1 GENE POLYMORPHISMS IN SUDANESE PREGNANT WOMEN WITH THROMBOSIS
Objectives: In this study we aimed to investigate whether P-selectin gene polymorphism is associated with thrombosis in Sudanese pregnant women in Khartoum state.Methods: After informed consent, 96 Sudanese pregnant wome...
SELECTIVE ANTICANCER ACTIVITY OF CURCUMA XANTHORRHIZA FERMENTED JUICES
Objective: The objective of this study was to investigate the anticancer activity and toxicity of fermented juices from six Thai plants, Garcinia mangostana Linn., Tinospora crispa Linn., Litchi chinensis Sonn., Dimocarp...
PHARMACODYNAMICS EFFECT OF METHYLPREDNISOLONE TABLETS ON THE SERUM CONCENTRATION OF ANNEXIN A1: IN VIVO COMPARATIVE STUDY BETWEEN GENERIC AND INNOVATOR DRUG
Objective: The aims of this study were to investigate the comparative pharmacodynamics effect of methylprednisolone (MP) innovator, MP branded generic, and MP generic products to the serum concentration of annexin A1 (An...
ISOLATION AND IDENTIFICATION OF NON-POLAR CHEMICAL ENTITY FROM LEPTADENIA RETICULATA AERIAL PARTS
Objective: Leptadenia reticulata is the medicinal plant having many biological activities. It is necessary to find out which types of phytochemical constituents are present in the plant. The objective of this investigati...