Safety, Feasibility, and Biomarker Effects of High-Dose Vitamin D Supplementation Among Women at High Risk for Breast Cancer
Journal Title: International Journal of Food Science, Nutrition and Dietetics (IJFS) - Year 2015, Vol 0, Issue 1
Abstract
Vitamin D deficiency is a potentially modifiable risk factor that may be targeted for breast cancer prevention. We examined the safety, feasibility, and biomarker effects of high-dose vitamin D among women at high risk for breast cancer. Forty high-risk women, defined as a 5-year breast cancer risk ≥1.67% per the Gail model, lobular or ductal carcinoma in situ, were assigned to a 1-year intervention of vitamin D3 20,000 IU or 30,000 IU weekly. Participants were monitored for toxicity every 3 months, underwent serial blood draws at baseline, 6 and 12 months, and a digital mammogram at baseline and 12 months. Biomarker endpoints included serum 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D [1,25(OH)2D], parathyroid hormone (PTH), insulin-like growth factor (IGF-1), IGF binding protein (IGFBP-3), and mammographic density (MD) using Cumulus software. From November 2007 to January 2011, we enrolled 40 women; 37 were evaluable at 6 months and 30 at 12 months. One patient was taken off study for hypercalciuria; otherwise, the intervention was well tolerated. From baseline to 12 months, mean serum 25(OH)D and 1,25(OH)2D rose from 20.0 to 46.9 ng/ml and 69.7 to 98.1 pg/ml, respectively (p<0.01). Serum PTH decreased by 12% at 6 months and IGF-1/IGFBP-3 ratio decreased by 4.3% at 12 months (p<0.05). There was no significant change in MD regardless of menopausal status or dose level. We demonstrated that 1 year of high-dose vitamin D3 was associated with a significant increase in circulating vitamin D levels and favorable effects on IGF signaling, but no significant change in MD.
Authors and Affiliations
Jacqueline Rudolph Germain
Physiological Effect of Chromium Exposure: A Review
Human exposure to metals is common due to their wide use in industry, and environmental persistence. The heaviest metal exposures occurred in the workplace or in environmental settings in close proximity to industrial so...
Sensory Evaluation of Gamma Irradiated Shrimp (Penaeus notialis) from Three Different Water Sources in Ghana
Shrimp is one of the world’s most popular shellfish. It is cherished in Ghana due to a wide range of culinary applications such as its usage as food as well as food condiments in some local foods such as kenkey (local fo...
Skipping Meals and its Possible Effects on Lipid Profile of Purposively Selected Civil Servants in Aba, Abia State, Nigeria
Skipping meals and its possible effects on lipid profile of purposively selected civil servants in Aba, Abia State, Nigeria was carried out by purposively selecting a total of 35 volunteer human adults. Questionnaires we...
Studies on Physico-Chemical Properties of Noni Fruit (Morinda Citrifolia) and Preparation of Noni Beverages
Noni (Morinda citrifolia linn) fruits are edible but they don’t have nice taste and flavor. In present investigation attempts have been made to standardize the recipes for preparation of noni beverages i.e. RTS, Squash a...
Effect of Pomegranate (Punica granatum L.) Seed Oil on Markers of Oxidative Stress Induced by Carbon Tetrachloride in Wistar Rats
The pomegranate seed oil (PSO) presents a high content of the punicic acid (PA), which is a conjugated isomer of α-linolenic acid (CLNA). Conjugated fatty acids have increasingly attracted scientific interest because of...