Salivary hexosaminidase B in children with type 1 diabetes
Journal Title: Progress in Health Sciences - Year 2012, Vol 2, Issue 2
Abstract
Introduction: Children type 1 diabetes is accompanied by inflammation and microangiopathy pro-ceeded with increased degradation of tissues. Nacetyl-β-hexosaminidase (HEX) is the most active of exoglycosidases degrading oligo-saccharide chains of glycoconjugates (glycoproteins, glycolipids and proteoglycans). Purpose: To evaluate the hexosaminidase B (HEX B) activity in the saliva of children with type 1 diabetes. Materials and methods: The study was performed in 35 children with type 1 diabetes and 20 healthy children. Salivary HEX B activity was determined by the colorimetric, and protein by bicinchoninic acid methods. The HEX B activity concentration was expressed in pKat/mL and specific activity in pKat/µg of protein. Results: A significant increase in the concentration and the specific activity of HEX B in the saliva of children with type 1 diabetes, as compared to healthy children, was found. Conclusion: Children suffering from type 1 diabetes have increased catabolism of salivary gly-coconjugates by HEX B, which potentially may be useful in the diagnosis of type 1 diabetes in children.
Authors and Affiliations
B Zalewska-Szajda, S Chojnowska, N Waszkiewicz, E Gościk, U Łebkowska, A Kępka, K Mierzyńska, SD Szajda, JR Ładny
Keywords
Related Articles
- EP ID EP75833
- DOI -
- Views 73
- Downloads 0
The therapeutic effects of mud
Mud baths have been known and used for thousands of years, but their mechanism is not fully understood. Mud therapy has been successfully used in the treatment of neurological, rheumatologic (osteoarthritis) and cardiova...
Quality of life of osteoarthritis patients in the aspect of analgesic treatment
<b>Introduction:</b> Osteoarthritis an inflammatory process in the synovial membrane. These changes cause pain and joint deformities. Pharmacists can assess patients’ quality of life, which can be a good criterion for as...
Predictive roles of coping and resilience for the perceived stress in nurses
Introduction: Nursing profession is physically and emotionally demandingPurpose:To determine the relationship between coping strategies and resilience, as well as perceived stress among nurses.Materials and methods: The...
Knowledge of and opinion on organ transplantation among priests of selected Christian religion
Introduction: As Polish society is in its majority Christian, the knowledge and attitudes presented by priests may have a tangible impact on Church mem-bers’ decisions concerning organ donation. Purpose: To evaluate the...
Sanitary and epidemiological surveillance in Poland from 1945 to 1989 (selected issues)
Introduction: In this article, selected issues concerning sanitary and epidemiological surveillance in post-war Poland (until 1989) have been described. Sanitary problems which occurred in Poland directly after the Secon...