Salivary Interferon Gamma and Interleukin-4 Levels in Patients Suffering from Oral Lichen Planus
Journal Title: Cell Journal(Yakhteh) - Year 2015, Vol 17, Issue 3
Abstract
Objective: Oral lichen planus (OLP) is a chronic inflammatory disease. Immunological factor may act as etiological factor. The cellular immune cells such as T cells are important in pathogenesis. Interferon gamma (IFN-γ) and interleukin 4 (IL-4) are secreted by T-helper 1 (Th1) and Th2, respectively. The aim of this study was to investigate the correlation between salivary levels of IFN-γ and IL-4 with OLP. Materials and Methods: This case control study included sixty three Iranian OLP patients who were selected from the Department of Oral Medicine of Ahvaz Jundishapur University of Medical Sciences from January to July 2013. An equal number of healthy volunteers were also selected as a control group. The OLP patients were then divided into two following sub-groups: reticular (n=30) and erythematous/ulcerative (n=33). All patients had no systemic disease and received no medication. IFN-γ and IL-4 levels in whole unstimulated saliva (WUS) were measured using the enzyme-linked immunosorbent assay (ELISA) test. Data analysis was done using t test, ANOVA, least significant difference (LSD) test, and the Kruskal-Wallis test. Results: Reticular OLP patients showed higher salivary IFN-γ (7.74 ± 0.09 pg/ml ) and IL-4 (3.876 ± 0.05 pg/ml) levels compared with the control group, indicating that difference was significant. Salivary IFN-γ/IL-4 ratio significantly increased compared with control group (P=0.042). Salivary IFN-γ and IL-4 levels between sub-groups (reticular and erythematous/ulcerative) were not significantly different (2.6 ± 0.06 and 2.3 ± 0.05, respectively, P<0.05). Conclusion: Salivary IFN-γ and IL-4 levels were increased in OLP patients. An increase of salivary IFN-γ/IL-4 ratio in OLP patients showed that Th1 might have a dominant role in the OLP pathogenesis.
Authors and Affiliations
Hossein Malekzadeh, Maryam Robati, Hojatollah Yousefimanesh, Mehri Ghafourian Boroujerdnia, Reza Nadripour
Keywords
Related Articles
- EP ID EP590310
- DOI 10.22074/cellj.2015.16
- Views 162
- Downloads 0
Correction: Transcription Profiles Of Marker Genes Predict The Transdifferentiation Relationship Between Eight Types Of Liver Cell During Rat Liver Regeneration
In this article which was published in Cell J, Vol 17, No 2, Summer 2015, on pages 339-354, the name of the first author was published incorrectly as: "Xiaguang Chen". The correct one is "Xiaoguang Chen". This correction...
Effect of The Receptor Activator of Nuclear Factor кB and RANK Ligand on In Vitro Differentiation of Cord Blood CD133+ Hematopoietic Stem Cells to Osteoclasts
Objective Receptor activator of nuclear factor-kappa B ligand (RANKL) appears to be an osteoclast-activating factor, bearing an important role in the pathogenesis of multiple myeloma. Some studies demonstrated that U-266...
DNA Methylation And Histone Acetylation Patterns In Cultured Bovine Adipose Tissue-Derived Stem Cells (BADSCs)
Objective Many studies have focused on the epigenetic characteristics of donor cells to improve somatic cell nuclear transfer (SCNT). We hypothesized that the epigenetic status and chromatin structure of undifferentiated...
Generation of Mouse Spermatogonial Stem-Cell-Colonies in A Non-Adherent Culture
Objective: The properties of self-renewal and division in spermatogonial stem cells (SSCs) support spermatogenesis. There is a number of reported methods for in vitro SSC culture systems. The development of a culture sys...
Effect of Plasma-Derived Exosomes of Refractory/Relapsed or Responsive Patients with Diffuse Large B-Cell Lymphoma on Natural Killer Cells Functions
Objective: The purpose of this study was to investigate effect of plasma-derived exosomes of refractory/relapsed or responsive diffuse large B-cell lymphoma (DLBCL) patients on natural killer (NK) cell functions. Materia...