Salivary Interleukin-6 Levels in Patients with Periodontitis Stage IV
Journal Title: Meandros Medical and Dental Journal - Year 2021, Vol 22, Issue 2
Abstract
Objective: The role of interleukin-6 (IL-6) in the pathogenesis of periodontal disease and tissue destruction at the periodontal site has been widely reported. This study aimed to evaluate the salivary IL-6 levels in patients with stage IV periodontitis. Materials and Methods: The study included 28 patients who were diagnosed with periodontitis stage IV and the control group of 22 periodontally healthy patients. All the patients were systemically healthy. Saliva samples were collected, and clinical periodontal measurements, including probing depth (PD), clinical attachment level (CAL), papilla bleeding index (PBI), the percentage of sites with bleeding on probing (BOP) %, plaque index (PI) and calculus index (CI), were recorded. The unstimulated saliva of each patient was collected by a saliva collector, and all samples were analysed using the enzyme-linked immunosorbent assay method for the detection of IL-6. Results: The mean value of salivary IL-6 in patients with periodontitis stage IV was 22.18±5.96 pg/mL. In the control group, the average measured value of IL-6 was 2.23±2.17 pg/mL. The periodontitis group had a significantly higher salivary IL-6 levels than the control group. A strong positive correlation was observed between the salivary IL-6 and clinical periodontal parameters (PD, CAL, PBI, BOP %, PI and CI) in patients with periodontitis stage IV (p<0.0001). Conclusion: We demonstrated a statistically significant relationship between periodontal parameters and salivary IL-6 in patients with periodontitis stage IV. New studies are needed to accurately establish salivary IL-6 potential as a biomarker for periodontal disease monitoring, including all stages and grades of periodontitis.
Authors and Affiliations
Zerina Hadzic, Enes Pasic, Mirsada Hukic, Mirjana Gojkov Vukelic, Sanja Hadzic
Keywords
Related Articles
- EP ID EP694412
- DOI 10.4274/meandros.galenos.2021.05945
- Views 108
- Downloads 0
Assessment of the Effects of Light and Sound Impulses on the Electrical Potential of the Eye and Ocular Muscles
Objective: The aim of this study is to determine the effects of visible light on the electrical potential of the eye and facial/ocular muscles using electrooculography (EOG) and the effects of visible light and sound sti...
Rational Use of Drugs Among Inpatients and Its Association with Health Literacy
Objective: Rational use of drugs (RUD) plays a vital role in the success of the treatment process. Considering that use of medicines is also related with decision making mechanisms of individuals, RUD and health literacy...
Examination of the Knowledge Levels, Attitudes and Anxiety Sources Regarding Coronavirus Disease-2019 Infection in Dentistry Students in Clinical Practice
Objective: This study aimed to examine and evaluate the knowledge levels, attitudes and anxiety sources regarding coronavirus disease-2019 (COVID-19) infection in dentistry students in clinical practice. Materials and M...
Awareness on the Effects of Periodontal Diseases on the General Health of Individuals with Systemic Diseases and Determination of Influential Factors
Objective: This study aimed to investigate the level of awareness regarding the effect of systemic diseases on periodontal diseases among individuals with systemic diseases. Materials and Methods: This descriptive study...
Does Medication-related Osteonecrosis of the Jaw Affect Maxillary Sinus Volume and Mucosal Thickness?
Objective: Bisphosphonates (BPs) are commonly prescribed drugs because of their antiresorptive effects. However, BPs may cause medication-related osteonecrosis of the jaw (MRONJ). This study aimed to compare the maxillar...