SALIVARY LIPID PEROXIDATION AND LIPID PROFILE LEVELS IN PATIENTS<br /> WITH RECENT ISCHEMIC STROKE
Journal Title: Journal of International Dental and Medical Research - Year 2010, Vol 3, Issue 2
Abstract
Abnormal lipid levels are an important risk factor in the development of atherosclerotic complications like stroke. Oxidative stress, lipid and lipoprotein Peroxidation are involved in neuronal damage induced by ischemia-reperfusion in stroke. Malondialdehyde (MDA) is widely utilized as a marker of lipid Peroxidation in state of elevated oxidative stress. The role of lipid in oxidative damage in saliva of patients with stroke is not yet completely elucidated. The aim of this study was evaluate the relationship of MDA as a marker of lipid Peroxidation with lipids and lipoprotein fractions and to find out the cut-off values of the studied parameters in saliva of patients with recent stroke . We studied 50 patients with ischemic stroke and other 25 ages and sex matched health control. To evaluate the oxidative status we measured the levels of Malondialdehyde in saliva and serum of all participants. Lipid profile was also estimated by the total cholesterol, triglycerides, LDL-C and HDL-C. MDA levels were significantly higher in patients with ischemic stroke than that of healthy control. Salivary critical value of triglycerides more than 0.5 mmol/L yields in highest accuracy rate (93%) to differentiate patients with ischemic from healthy control , followed by salivary MDA values which should be equal to or more than 0.38 μmol/L to be helpful in differentiation between two groups with (92% accuracy). Assessment of salivary lipid Peroxidation together with salivary lipid profile may be useful in early detection and monitoring of patients with increased risk of stroke.
Authors and Affiliations
Natheer Al-Rawi
Keywords
Related Articles
- EP ID EP155148
- DOI -
- Views 115
- Downloads 0
EVALUATION OF DENTAL WASTE MANAGEMENT IN THE EMIRATE OF AJMAN, UNITED ARAB EMIRATES
THE EFFECT OF NaF 5% AND NANONaF TO THE PERMANENT TOOTH ENDURANCE TOWARD DENTAL CARIES
NaF 5% is a fluoride that commonly used as a dental topical application treatment. As the technology develops nowadays, nanoparticle is possibly used as dental material because it has greater penetration to ename...
COMPARATIVE EVALUATION OF DIAMETRAL TENSILE STRENGTH OF PHOSPHATE BONDED INVESTMENT MATERIALS AFTER DRYING BY VARIOUS METHODS”–AN INVITRO STUDY
The study is to evaluate and compare the Diametral Tensile strength of Phosphate bonded Investment materials (Wirovest, Cromocasting Fast and Accuvest) after drying by Air dried method, Conventional Hot air ov...
OUR DIAGNOSTIC AND THEARAPEUTIC SURGICAL APPROACHES TO MEDIASTINAL MASSES
The mediastinum is defined as the thoracic space that lies between the two pleural layers. It extends from the thoracic inlet to the superior surface of the diaphragm. It is bordered anteriorly by the internal surface of...
THE EFFECT OF IMMUNOSUPPRESSION AGENTS ON STEM AND ENDOTHELIAL CELLS’ PROLIFERATION IN VITRO
The control of immune-mediated transplant rejection by immunosuppressive agents might affect other human cells’ proliferation and function. This study aims to evaluate the effect of three immunosuppressants on th...