Salvigenin has Potential to Ameliorate Streptozotocin-induced Diabetes Mellitus and Heart Complications in Rats
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 15, Issue 2
Abstract
Objectives: Flavonoids are the active ingredients, found in herbal remedies for amelioration the variety of disorders. Salvigenin is a plant flavenoid, which is found in Salvia officinalis. Salvigenin has an antioxidant, anti-inflamatory, anti-tumor and vascular relaxant activities. This study was conducted to evaluate the possible antidiabetic and cardioprotective effects of salvigenin. Materials and Methods: 32 wistar rats were made diabetic using streptozotocin (60 mg/kg, i.p.). Rats were divided into four groups that treated with salvigenin at doses of 5, 10 or 25 mg/kg. All the treatments were administered orally for 4 weeks. At the end of the experiment, the blood samples were collected for determining the FBS, HbA1C, insulin, triglyceride, cholesterol and HDL. After 72 hrs, animals were anesthetized; hearts were removed quickly and mounted on Langendorff apparatus. The max pressure, heart rate, max dP/dt, contractility index and coronary flow were measured. Results: Administration of salvigenin exhibited a significant reduction in fasting serum glucose, triglycerides, total cholesterol, HbA1c and increased level of plasma insulin and HDL in diabetic rats (P<0/05). Salvigenin could significantly increased hemodynamic indices such as max pressure, max dP/dt, contractility and coronary flow (P<0/05). Conclusion: Salvigenin improved diabetes through decreasing blood glucose, lipid profile, HbA1c. Increased insulin secretion can be a mechanism for antidiabetic effect of salvigenin. Regarding the antidiabetic and cardioprotective effects of salvigenin, it can be concluded that this flavonoid compound can be potentially used to reduce diabetes and it’s cardiovascular complications.
Authors and Affiliations
Hamid Mohammad Sadeghi, Amirhossein Mansourabadi, Mohammad Ebrahim Rezvani, Mojtaba Ghobadi, Nastaran Razavi, Mahmood Bagheri
Keywords
Related Articles
- EP ID EP341180
- DOI 10.9734/BJMMR/2016/25156
- Views 54
- Downloads 0
ARMS-PCR Based SNP Analysis of MTHFR C677T Allele Using Syber Green in Pancreatic Tumour
In human, carcinoma of pancreas, a rare disease and mortality rate is quite high in Indian population. Epidemiological studies support the hypothesis that folate metabolism regulate DNA stability and prevent cancer. Beca...
Awareness and Assessment of Work-related Hearing Impairment among Dental Professionals in Kano-Nigeria
Background: Dentist and allied professionals are undoubtedly among professional groups at risk of noise- induced hearing impairment in the workplace. There has been speculation about the relationship between hearing loss...
Structural Correlates of Depressive Symptoms in Prodromal Alzheimer’s Disease
Background/Aims: We conducted a cross-sectional study to investigate the structural magnetic resonance imaging correlates of depressive symptoms at the initial clinical stages of Alzheimer’s disease (AD). Methods: Subje...
Analysis of Atherogenic and Anthropometric Profiles of Normotensive and Hypertensive Ghanaians in the Kumasi Metropolis
Ghana is undergoing a rapid epidemiological transition from solely communicable to a double burden of infectious and chronic disease such as hypertension. Aims: We aimed to compare the association between different life...
Incidence of Intoxication in Karabuk (Turkey) in 2013
Aims: The aim of this retrospective study was to analyze the rate and characteristics of intoxications who were admitted to our intensive care unit (ICU). Study Design: This is a retrospective study. Place and Duration o...