Sapindus emarginatus extract embedded with gold nanoparticles: an antiproliferative agent against MCF7 breast cancer cell line
Journal Title: Materials Physics and Chemistry - Year 2019, Vol 1, Issue 2
Abstract
There are numerous studies reported on the usage of the Sapindus emarginatus (SE) fruit in cancer and other treatments in the past few years. In this study, crude SE fruit extract was prepared and it was further used to synthesis gold nanoparticles (Au Nps). The synthesized Au Nps were left embedded in the SE fruit extract. The Au Nps embedded in the SE fruit extract (SE-Au Nps) were characterized using UV Vis spectroscopy, Centrifugal particle size analyzer (CPS), Scanning Electron Microscope (SEM) and Fourier Transform Infrared Spectroscopy (FTIR). MTT assay was carried out for both SE fruit extract and SE-Au Nps on MCF7 breast cancer cell line and compared. The UV- Vis Absorbance for the SE-Au Nps was obtained at 543nm. The centrifugal particle size analysis of the Au Nps embedded in SE fruit extract showed the size of the nanoparticles to be widely varying with higher fraction of particles between the size ranges of 15 to 20nm. The morphology of the Au Nps embedded in SE fruit extract was observed using SEM. The presence of Au Nps in SE fruit extract was confirmed using FTIR. The results of the MTT assay on MCF7 breast cancer cell line proved that the %cell viability was less for SE-Au Nps than that of the SE fruit extract alone. Thus the antiproliferative activity of the SE fruit extract was significantly enhanced by embedding it with Au Nps and it can be effectively used in therapeutic applications after further studies.
Authors and Affiliations
S. Vignesh Kumar, V. Kavimani
Keywords
Related Articles
- EP ID EP680116
- DOI -
- Views 251
- Downloads 0
Investigation of Mechanical Properties of Friction-welded AISI 304 with AISI 430 Dissimilar Steels
In this paper, standard SS304 austenitic stainless steel and SS430 ferritic steel cylindrical rods were fabricated by friction welding process by varying the frictional pressure and forge pressure in order to understand...
Desulfurization of the dibenzothiophene (DBT) using imidazoliumbased ionic liquids (ILs)
In this work we examined the industrial scale extraction process of ultra-low sulfur diesel with the help of simulation software ASPEN Plus®. This work focuses on the [Cnmim] [BF4] (imidazolium-based) ionic liquid and em...
Mathematical Modeling of Hydraulic Resistance in Pipes with Rough Walls
In recent years, the numbers of patents have been devoted to the development of rough pipes. The technique theoretical settlement determine of factor of hydraulic resistance for round pipes with rough walls is developed...
Perspective Material for Photoenergetics on the Basis of Silicon with Binary Elementary Cells
The paper proposes a scientifically-grounded, principally-new approach to managing the fundamental parameters of the basic material of electronic engineering as like silicon. The essence of the proposed approach is the f...
Numerical simulation of macrosegregation impurities in the solidifying continuous casting steel billet
In this study, new theoretical conceptions have been developed about an impurity segregation mechanism at the time of alloy solidification considering present microvolumes with different chemical compositions during allo...