Screening of cardioprotective activity of leaves of Andrographis paniculata against isoproterenol induced myocardial infarction in rats
Journal Title: International Journal of Pharmacological Research - Year 2016, Vol 6, Issue 1
Abstract
Objective: The objective of the present study was to investigate the cardioprotective effects of methanolic extract of leaves of Andrographis paniculata against Isoproterenol-induced myocardial infarction (MI) in rats. Method: The rats were divided into five experimental groups viz., Normal control, ISO-treated (Disease control), Propranolol (10 mg/kg + ISO), Andrographis paniculata (100 mg/kg +ISO) and Andrographis paniculata (200 mg/kg + ISO). Myocardial infarction in rats was induced by the administration of isoproterenol at a dose of 85mg/kg i.p., the rats in group IV and group V were pretreated with methanolic extract of Andrographis paniculata in the dose of 100mg/kg b.w. and 200mg/kg b.w. through oral route. Cardiac marker enzymes, lipid profile and antioxidant enzymes as biomarker of cardiotoxicity were determined in experimental animals. Result: Animals treated with flavonoid of leaves of Andrographis paniculata showed significant decrease in LDL-Cholesterol, total cholesterol, Triglycerides, AST, ALT, ALP, antioxidant enzymes viz., superoxide dismutase, catalase LPO and increase in HDL-Cholesterol and further was confirmed by histopathological study. Conclusion: The results of the study demonstrate that Andrographis paniculata strongly protected the myocardium against isoproterenol-induced infarction and suggest that the cardioprotective effects could be related to antioxidant activities.
Authors and Affiliations
Dipendra Kumar Sah, Nagarathana P. K. M.
Keywords
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- EP ID EP435215
- DOI 10.7439/ijpr.v6i1.2898
- Views 63
- Downloads 0
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