Screening of Extractable Nuclear Antibodies by ELISA in Patients with Connective Tissue Disorders in a Tertiary Care Hospital
Journal Title: International Journal of Current Microbiology and Applied Sciences (IJCMAS) - Year 2018, Vol 7, Issue 3
Abstract
Autoimmune diseases occur in 3–5% of the population as a result of myriad of genetic and environmental factors that lead to altered immune reactivity. The alterations in the immune system initiated by a loss of immunological tolerance to self-antigens lead to the development of autoreactive phenomena that can be detected in the peripheral blood. The present study was undertaken to detect the Extractable Nuclear Antibodies present in the study population. This study was conducted for a period of 1 year in 100 patients attending Rheumatology department. 50 patients had signs and symptoms related to connective tissue disorders and were ANA positive. Another 50 patients had no signs and symptoms related to CTD and were ANA negative. Out of 100 patients tested, 28 (56%) of ANA positive patients and 3 (6 %) among control group were found to be positive for extractable nuclear antibodies by ENA screening ELISA. Among ENA positive subjects most common age group was 30-39 years that is 38.7% were in this age group. Extractable Nuclear Antibodies were found most predominantly in females (28 out of 31) 90.3% compared to males (3out of 31) 9.7%. Autoimmune connective tissue diseases are rare group of diseases with significant impact on patient’s quality of life and socioeconomic aspects. Antibodies against extractable nuclear antigens (ENAs) are useful diagnostic markers for various autoimmune connective tissue diseases.
Authors and Affiliations
S. Punitha Ranjitham, I. M. Rejitha, G. Sucilathangam, C. Revathy
Keywords
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- EP ID EP574352
- DOI 10.20546/ijcmas.2018.703.012
- Views 67
- Downloads 0
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