Second malignant neoplasm in a treated Ewing sarcoma patient: A case report
Journal Title: Indian Journal of Child Health - Year 2018, Vol 5, Issue 6
Abstract
Ewing sarcoma (ES) is an aggressive tumor commonly seen in children and young adults. Late effects of ES therapy include the second cancers, a tragic outcome for survivors of such young age. We report a case of a 3-year-old male child who presented with a right maxillary mass extending to the orbit. Fine-needle aspiration cytology and tru-cut biopsy showed features suggestive of a small round cell tumor. Immunohistochemistry confirmed the diagnosis of ES/primitive neuroectodermal tumor. The patient was started on non-metastatic Ewing family tumor protocol with intensity-modulated radiotherapy and responded well to therapy. He was followed up regularly, but after 5 months of initial diagnosis, his peripheral blood smear showed atypical cells resembling blasts. His bone marrow aspiration (BMA) and biopsy showed marrow infiltrated by hematolymphoid malignancy. Based on the positivity of the blasts for myeloperoxidase and non-specific enolase in cytochemistry on the BMA and flow cytometric analysis, a diagnosis of acute myeloid leukemia with monocytoid differentiation was made. We report this case to emphasize the role of the pathologist in differentiating the second malignancies from recurrence of the first malignancy or therapy-related changes, especially in the case of an equivocal morphological picture.
Authors and Affiliations
Kakoti Lopa Mudra, Choudhury Zachariya, Sharma Jagannath
Keywords
Related Articles
- EP ID EP465550
- DOI -
- Views 64
- Downloads 0
Fast food is not the only junk food: Consumption pattern of different types of junk food in adolescents of Aligarh
Background: Junk food is a term that is used for many types of food including the predominantly western - fast foods, as well as for local - street foods and instant foods. Objectives: The objectives of this study were t...
Bilateral ureteropelvic junction obstruction: Factors guiding management
Background: The management of prenatally detected hydronephrosis due to bilateral ureteropelvic junction obstruction (UPJO) remains controversial. No definite recommendations exist regarding management, and many authors...
Tetra-Amelia syndrome with congenital diaphragmatic hernia - A rare entity
Tetra-Amelia syndrome is a very rare disorder characterized by the absence of all four limbs. “Tetra” is the Greek word for “four” and “Amelia” refers to the failure of an arm or leg to develop before birth. This syndrom...
Spinal cord atrophy and myelomalacia following triple intrathecal chemotherapy in a patient of relapsed acute lymphoblastic leukemia
Paraplegia in a case of leukemia is an uncommon finding. It can be disease related, therapy related, or both. It may or may not be reversible or curable. Here, we are discussing an unusual acute life-threatening, therapy...
Calcified liver abscess in a newborn with portal vein thrombosis and portal cavernoma
Liver abscess in the neonatal period is a rare but serious illness. We present a case of liver abscess in a 30 week preterm infant after necrotising enterocolitis and umblical venous catheterization. It was later complic...