Secondary Glioblastoma Multiforme - Small Cell Type with Distant Metastases and Good Response to Temozolamide - A Case Report
Journal Title: GUJARAT CANCER SOCIETY RESEARCH JOURNAL - Year 2013, Vol 15, Issue 1
Abstract
Glioblastoma multiforme (GBM) is one of the most aggressive brain neoplasms. Extracranial metastases are rarely described in GBM. We report a case of secondary GBM with cervical lymph node and bone metastases with good disease control by chemotherapy. Our patient is a 30-year-old female with secondary small cell type GBM. Patient was operated for the same. One and half years later patient presented with lymph node and skeletal metastasis, with lymph node histology consistent with GBM metastases. Skeletal metastasis was diagnosed on positron emission tomography (PET) scan done in view of pain in back and left lower limb. Chemotherapy (Temozolamide- 150mg/m2/day for 5days every four weeks) was started after which the patient's clinical course has been stable. The lesion in the brain remained quiescent meanwhile. The interesting facts about our case are development of extra cranial metastasis due to secondary GBM, a rare event, and the fact that the patient continues to enjoy a reasonable quality of life for two years despite developing systemic metastasis as the primary tumor remained quiescent
Authors and Affiliations
Pranshuta Sharma, Anuja Gupta, Priti Trivedi, Manoj Shah, Deepak Patel
Keywords
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