Seizures, Hepatotoxicity and Advanced Disease Are the Greatest Predictors of Death in Tubercular Meningitis
Journal Title: Indian Journal of Medical and Health Sciences - Year 2017, Vol 4, Issue 2
Abstract
The prevalence of Tuberculous meningitis is increasing in developing countries including in India. Many complications, long term sequelae and deaths are associated with tuberculous meningitis. Our aim is to access the complication in different stages of tuberculous meningitis and to identify the predictors of mortality. Method This prospective study was conducted in tertiary care hospital, Eastern India from (May2013- June 2016). Study included patients suffering from tuberculous meningitis proved by history, clinical examination, CSF study and radiological imaging. The patients were then classified according to different stages of tuberculous meningitis and observed for the complications including seizures and drug induced hepatitis and mortality differed between the three stages. All the patients were put on treatment and followed up. Result A total of 100 cases were enrolled in which 54 were males and 46 females with median age 29.2+11.15 years. 36%, 37% and 27% of patients presented in stage I stage II and stage III respectively. 46% developed hydrocephalus, 29% had cranial nerve palsy, 24% had stroke, 23% had seizures, 17% developed tuberculoma, 13% had hypodensities suggestive of vasculities and basal exudates were seen in 33%. 17 patients were died during hospital stay and 83 patients were discharged. Conclusion our study showed the disease is more prevalent in younger population equally affected males and female. The rate of central nervous system complication is high every complication contributes to morbidity and mortality but the greatest predictors are seizure, stroke, drug induced hepatitis and advanced stage of disease.
Authors and Affiliations
Ritwika Majumdar
Keywords
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- EP ID EP455795
- DOI 10.21088/ijmhs.2347.9981.4217.2
- Views 113
- Downloads 0
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