Seroprevalence of HSV-2 in STI Clinic Attendees and Non High Risk Controls in a Tertiary Care Hospital in North India
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 3
Abstract
Introduction: Herpes Simplex Virus-2 is one of the major cause of Sexually Transmitted Infections leading to genital ulcer disease. Thus, an understanding of the pattern of STIs prevailing in different geographic regions of a country is necessary for implementation of STI control strategies. Therefore, seroprevalence of HSV-2 IgM and IgG in both cases and control group was studied along with the sociodemographic characteristics and proportion of primary and recurrent genital herpes. Material and Methods: A prospective study was conducted in Department of Microbiology, G.M.C., Amritsar on blood samples obtained from 250 patients attending STI clinic and on 50 control group subjects attending Department of Skin and STD from Dec2015 to June 2017. Serological testing by ELISA for HSV-2 IgM and IgG antibody against glycoprotein G2 was performed. Results: out of 250 cases, seroprevalence of HSV-2 IgM and IgG was 8.4% and 14% respectively. 35.7% cases of primary genital herpes and 64.3% recurrent genital herpes cases were observed. Male preponderance was noticed with maximum number of cases in the age group of 40-49years. Out of 50 controls, seroprevalence of HSV-2 was 8% (p<0.05). Conclusion: Due to the asymptomatic nature of HSV-2 and continuous shedding of the virus in majority of cases, there is a strong need to screen the vulnerable population like STI clinic attendees and other high risk groups for HSV-2 to protect the patients themselves and non-infected partners from acquiring these infections.
Authors and Affiliations
Anuja Gupta, Sita Malhotra, Loveena Oberoi, Tejinder Kaur, S. K. Malhotra, Pushpa Devi
Keywords
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