Serum Aluminium Levels in Stage 4, 5 & 5D Chronic Kidney Disease
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 4
Abstract
Objectives: Use of non aluminum containing phosphate binders and improvement in feed water quality for hemodialysis (HD) have resulted in low prevalence of aluminum toxicity. The study was undertaken to detect the prevalence of high serum Al levels in chronic kidney disease (CKD) patients & controls. Settings & Design: Cross sectional study carried out at a tertiary care teaching hospital. Methods: We analyzed the serum aluminum levels in 32 CKD patients & 32 controls. It was one time sample check. The levels were correlated with anemia, Serum PTH levels, neurologic features if any. Iron status was noted in all. Results: All 32 CKD patients were anemic with Hb levels between 7 to 10 gm%. None were on any medication containing aluminum. Al level in our institute tap water & R.O. Water was < 5μg/l. Six volunteers showed Serum Al level range between 5 to15 μg/l while it was undetectable in remaining 26 volunteers. All 32 CKD patients had Serum Al > 5μg/l: 23 with 5 to 40 μg/l, 8 with 40 to 200 μg/l & one > 200 μg/l. Of 23 pts [in range 5 to 40 μg/l], 19 were on Maintenance HD while 4 were pre –HD. All 8 patients [in range 40 to 200 μg/l] & the one with S.Al > 200 μg/l were on HD. The difference in serum aluminium levels in two groups [Control Vs CKD] was significant (p< 0.001). The co-relation between serum Al level and Calcium (p- 0.21), as well as iPTH (p- 0.42) were not significant. None had any neurologic features. Conclusions: Serum aluminum was detectable in only 23% of controls but 100% in CKD patients. Though detectable, the levels were not significant in controls. However, 28% of CKD had S.Al >40 μg/l. Though it is a small study group, it highlights significantly higher levels, the source of which needs to be looked into.
Authors and Affiliations
Sandip P. Bhurke, Kalpana S. Mehta, Rudramani Swami, Amol Bhagat, Atim Pajai
Keywords
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- EP ID EP546849
- DOI 10.21276/ijmrp.2017.3.4.038
- Views 84
- Downloads 0
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