SERUM AND GASTRIC TISSUE ELECTROLYTE LEVELS IN CARBIMAZOLE-TREATED AND LEVOTHYROXINE-TREATED MALE NEW ZEALAND WHITE RABBITS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 10
Abstract
Thyroid and gastrointestinal tract functions are connected in both health and disease conditions. Thyroid hormones regulate metabolic function; therefore its disorders are associated with electrolyte imbalance. This study provides scientific information on gastric tissue electrolyte level, and its relationship with serum electrolyte level in altered thyroid state. It also documents the effect of dysthyroidism on adherent gastric mucus content, a gastro protective factor, and gastric architecture. Fifteen healthy male New Zealand White Rabbit of comparable weight were randomly allocated into three (3) groups (n=5), Control, Carbimazole-treated (5mg/250g bw) and Levothyroxine-treated (5μg/100g bw) groups. Treatments were given orally for 35 days. Thyroid function test, body weight change, serum and stomach tissue electrolyte, adherent gastric mucus content, oxidative stress parameters and histology of the stomach were assessed at the end of the treatments. There was a significant rise in gastric levels of chloride and bicarbonate in hyperthyroidism. These electrolytes significantly declined in hypothyroidism. However, gastric sodium level significantly declined in hyperthyroidism. Adherent gastric mucus content significantly increased in hyperthyroidism, but reduced in hypothyroidism. Dysthyroidism led to significant rise in MDA and depletion of catalase and GSH. Hypothyroidism also led to loss of parietal cells and marked gastric ulceration. It was concluded that the alteration in the gastric levels of electrolytes explains the gastric dysfunction seen in altered thyroid state. This is associated with lipid peroxidation.
Authors and Affiliations
Ajayi Ayodeji Folorunsho
Keywords
Related Articles
- EP ID EP628037
- DOI -
- Views 133
- Downloads 0
CONCEPTUAL STUDY OF KUTHIRAI VALI NOI (GRANDMAL TONIC CLONIC SEIZURE) IN SIDDHA MEDICINE
Epilepsy is common neuroleptic disorder with high prevalence. The disease and management having high impact on quality of life of affected person. It has been estimated that about 7%-8% of the population experiences at l...
MAGNETIC MICROSPHERES: A NOVEL DRUG DELIVERY SYSTEM
A well designed controlled drug delivery system can provide a therapeutic amount of drug to the proper site in the body and then maintain the desired drug concentration for the specific period of time. A number of approa...
MEDICAL PRESCRIPTION: ERRORS DETECTED IN NATIONAL HEALTH INSURANCE CENTRAL HOSPITAL OF ASUNCIÓN PARAGUAY
This paper aims to describe errors in medical prescriptions (EMP) issued by various medical professionals and the interventions in the Pharmacy of the Central Hospital of the Social Security Institute (HC-IPS) of Paragua...
PHYTOCHEMICAL SCREENING AND ANTIMICROBIAL EFFECTS OF LEAF FRACTIONS OF COMBRETUM MOLLE (R.BR. EX.G.DON) ON SOME SELECTED MICROBES
This work was carried out with the aim of determining the phytochemical compounds present in the aqueous, n-butanol and the ethyl-acetate fractions of the leaves of Combretum molle and their biological activities against...
SIMULTANEOUS DETERMINATION OF ANAESTHETIC AND ANTIBOTIC IN FLUID BY ELECTOCHEMILUMINESCENCE COUPLING CAPILLARY ELECTROPHORESIS
The coupling of electrochemiluminescence (ECL) with capillary electrophoresis (CE) was developed for the simultaneous determination of lidocaine and lomefloxacin in human urine. Under the optimized conditions: ECL detect...