Serum Ferritin: An Early Marker of Insulin Resistance in Metabolic Syndrome
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 2
Abstract
Background: Metabolic syndrome (MetS) is a combination of conditions that include hyperinsulinemia, obesity, dyslipidemia, and hypertension. Increased body iron stores are associated with the development of glucose intolerance, type 2 diabetes mellitus, and insulin resistance (IR) syndrome. Ferritin, being an acute phase reactant, has a tendency to increase in inflammatory conditions. Although the etiopathogenesis of MetS have been linked to iron overload and IR, controversy exists about the levels of ferritin in MetS. Hence, we aimed to estimate the levels of ferritin in cases of MetS and to correlate their levels with the individual components of MetS. Materials and Methods: This Case–control study included a total of 140 participants with 70 cases and 70 controls. Cases were selected on the basis of modified the National Cholesterol Education Program Adult Treatment Panel III Criteria. Their fasting blood samples were collected to estimate blood sugar, iron, ferritin, and insulin. IR was calculated using homeostasis model assessment IR (HOMA-IR) formula. Statistical analysis was performed by independent t-test, Mann–Whitney U-test, Pearson’s correlation test, and Spearman’s correlation test. Results: Serum ferritin, iron, insulin, and HOMA-IR were significantly high (P < 0.001) in cases when compared to controls. We found a significant positive correlation between iron levels and HOMA-IR ([r = 0.846, P < 0.001] and [r = 0.432, P = 0.010]) in males and females, respectively. Similarly, we found a significant positive correlation between ferritin levels and HOMA-IR ([r = 0.705, P < 0.001] and [r = 0.509, P = 0.002]) in males and females respectively. Conclusion: Serum ferritin plays a key role in the pathogenesis of MetS and could be used as a marker for early diagnosis of MetS.
Authors and Affiliations
J Sivasankari, V Thiruchelvan
Keywords
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