SERUM FETUIN- A LEVEL AND RENAL IMPAIRMENT INDUCED BY OBESITY IN COMPARISON WITH RENAL IMPAIRMENT INDUCED BY GENTAMICIN IN RATS.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2018, Vol 6, Issue 2
Abstract
Aim of the work: is to investigate the relation between serum fetuin-A level and renal impairment induced by obesity in comparison with that induced by gentamicin in rats and to determine the effect of fenofibrate treatment. Materials and Methods: 58 male rats were divided into four groups Control group: 15 rats were fed standard chow diet. Obese group 13 rats were fed a High fat diet (HFD). Then, albumin/ creatinine ratio (ACR) was done and according to the result of this test, this group was diagnosed as obese group with renal impairment. Fenofibrate treated obese group: 15 rats were fed a HFD along with fenofibrate. Gentamicin induced renal impairment group: 15 rats were fed stander chow diet. In the last eight days they were injected intraperitoneally with gentamicin. Body mass index (BMI) was measured. Urine was collected albumin, creatinine were measured in urine, blood was collected and serum urea, creatinine, fetuin-A, adiponectin, tumor necrosis alpha (TNF-?), malondialdehyde (MDA), reduced glutathione, fasting glucose, insulin, HOMA IR, lipid profile, calcium, phosphorus and solubility product were measured. Results: Fetuin ?A was significantly increased in obese group with renal impairment. This group also showed significant increase in ACR, serum urea, creatinine and phosphorus. Also, there was positive correlation between serum fetuin-A and BMI, ACR with a negative correlation between it and adiponectin. Also, it showed significant decrease in adiponectin, reduced glutathione and HDL and significant increase in BMI, TNF-?, MDA, Insulin, HOMA IR, triglyceride, LDL. However, fenofiberates intervention was associated with significant correction of all these parameters. In gentamicin induced renal impairment group, there was only significant increase in ACR, serum urea, creatinine, TNF-?, MDA and significant decrease in reduced glutathione. Fetuin-A shows no significant change when compared to control group. Conclusion: Fetuin-A may be associated with obesity-related renal impairment. So, more researches should done to investigate whether reduction of serum fetuin-A may hamper the development and progression of obesity-related complications or not. Also fenofibrate is found to be protective to renal impairment with obesity.
Authors and Affiliations
Rehab Ahmed Ahmed El-, Shaer
Keywords
Related Articles
- EP ID EP279408
- DOI 10.21474/IJAR01/6619
- Views 67
- Downloads 0
RESISTANCE PROFILE OF ENTEROBACTERIACEAE ACQUIREDIN URINARY TRACT INFECTIONS IN A REGIONAL HOSPITAL IN TANGIERSNORTHERN MOROCCO.
Urinary tract infections are the most recorded infections in the microbiology laboratory. The enterobacteria are the most commonly isolated bacteria in these types of infections. The present work aims to study the freque...
THE EFFECT OF COMPENSATION, COMPETENCE, AND TALENT MANAGEMENT ON EMPLOYEES PERFORMANCE OF THE IKATAN MOTOR INDONESIA.
As a facilitator of the sports industry, Ikatan Motor Indonesia (IMI) should be supported by qualified resources so that the human resource management technique can be run properly and correctly. Based on primary and sec...
SIMPLIFIED MEASUREMENT OF GRAVITY ACCELERATION BASED ON ELECTROMAGNETIC INDUCTION PRINCIPLE.
There are many methods for measuring gravity acceleration in physics experiments. These methods require special experimental instruments.Based on electromagnetic induction principle, this paper introduces a method using...
FUNCTIONAL AND ESTHETIC REHABILITATION WITH CROWNS AND FIXED PARTIAL DENTURE: A CASE RE-PORT
International Journal of Advanced Research (IJAR)
A PERVASIVE REVIEW OF THE CUSTOMER CONTENTMENT IN THE BHILWARA BANKING SECTOR.
The customer contentment is one of the most significant factors in business. When it comes to commercial banks, customer contentment level disassemble one bank from another, thus measuring customer contentment is exceedi...