Serum Gamma Glutamyl Transferase levels in Obese South Indian adults with reference to atherogenic lipid risk factors and lipid peroxides
Journal Title: International Journal of Medical and Health Sciences - Year 2012, Vol 1, Issue 2
Abstract
Background: Obesity has reached epidemic proportions especially in South India. In recent years, Waist circumference (WC), which reflects central obesity, has been regarded as an independent predictor of risk. Generation of free radicals occurs in central obesity and depletes intracellular glutathione, thereby inducing the production and release of Gamma Glutamyl Transferase [GGT] into circulation. High GGT levels are known to be associated with Type 2 Diabetes mellitus, hypertension and related vascular complications. Hence, this study was planned with a view to exploring the nexus among these components of metabolic syndrome and serum GGT levels, especially as the characteristic biochemical events are not fully understood and addressed yet. Materials and methods: In this prospective study we included 41 obese and 39 non-obese adults who were non-smokers and non-alcoholics, between the ages of 20 and 40 years. Lipid profile, Malondialdehyde (MDA), Fasting Plasma Glucose (FPG), blood pressure (BP) and GGT activity were measured in both the groups. Data were compared with un-paired student t-test. Pearson’s correlation was used to find the association of serum GGT levels with other variables in obese individuals. Results: Atherogenic dyslipidemia was documented in obese individuals which was associated with significantly elevated levels of serum GGT (p<0.001). High levels of serum GGT were also associated significantly with increase in BP (p<0.001), Lipid peroxidation [(serum MDA), (p<0.05)] and atherogenic lipid ratios [(TC/HDL, LDL/HDL) (p<0.001)]. Conclusions: Elevated serum GGT levels are associated with the components of metabolic syndrome and high degree of lipid peroxidation in obese South Indian adults.
Authors and Affiliations
Niranjan Gopal, Ajeet Selvam, Srinivasan A R, Saha S, Prakash H Muddegowda
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