Serum homocysteine and its association with various biochemical parameters in type 2 Diabetes Mellitus.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 8
Abstract
Aim: Homocysteine is a marker of endothelial dysfunction, which is suggestive of cardiovascular complications. In this study, we aimed to assess the role of homocysteine in the development of cardiovascular complications in type 2 diabetes. Patients and methods: Total 100 Patients were recruited in this study following the exclusion and inclusion criteria.. 50 test subjects, diagnosed with type 2 Diabetes according to the American Diabetes Association (ADA) revised criteria 2016 and 50 healthy controls of both gender and age comparable to test group, were selected. Plasma blood sugar in fasting and postprandial sample, HbA1C and serum lipid profile were estimated by colorimetric method on the fully automated analyzer. Serum Hcy was done by chemiluminescence method. Results: Diabetic subjects had significantly increased serum homocysteine, serum cholesterol, serum triglycerides (TG) and serum low density lipoprotein (LDL) (p<0.001). High density lipoprotein (HDL) was statistical insignificant and slightly lower in subjects with diabetes. Serum low density lipoprotein (LDL) (p<0.001) levels were significantly higher in the subjects having Homocysteine levels > 15 µmol/l. Conclusions: Homocysteine has an important role in the development of cardiovascular complication and significantly increases levels of Homocysteine in diabetic subjects suggests that this marker can be used for early identification of diabetic patients at risk of developing such complications.
Authors and Affiliations
Ankur Mathur
Keywords
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