Serum Magnesium Level As A Predictor Of Micro & Macro Vascular Complications Of Type 2 Diabetes Mellitus And Its Relation To Atherosclerosis
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 5
Abstract
Background: Diabetes Mellitus is a common condition; it causes symptoms that reduces the functional capacity of the bodily systems & negatively affects the quality of life. The risk of atherosclerosis & other forms of diabetic complications increases with reduced levels of serum Magnesium. So, we have designed the study to see the effect of serum magnesium levels on micro & macro vascular complications of Diabetes Mellitus & its relation to atherosclerosis. Material & Methods : A CASE CONTROL study was done, in which subjects with DM type 2 attending medicine OPD and admitted in Mahatma Gandhi Medical College were taken as cases also of age group above 30 years.Results : In our study showed that the mean age was 51 years of cases and male to female ratio was 2.12:1. The microvascular complication such as diabetic retinopathy, neuropathy & nephropathy was 26%, 18% & 22% cases present with hypomagnesemia (<1.8mg/dl) and 14%, 20% & 12% present with normomagnesemia (1.8-2.5 mg/dl). The macrovascular complication such as MI,PVD & CVA was 16%, 14% & 14% cases present with hypomagnesemia (<1.8mg/dl) and 6%, 4% & 2% present with normo-magnesemia (1.8-2.5 mg/dl). The mean serum magnesium levels in patients with HbA1c levels ≥ 8.5% were significantly low (1.561±0.38 mg/dL) compared to patient with HbA1c levels 6.5 to 6.99% . Conclusion : There was a strong correlation between hypomagnesemia and microvascular complications (diabetic retinopathy, nephropathy and neuropathy). Hypomagnesemia may be an independent risk factor responsible for the development of microvascular and macrovascular complications, to prove, further studies may be required.
Authors and Affiliations
Dr. Aashish Sharma, Dr. D. P. Bansal, Dr. Ram Kishan Jat, Dr. Chandra Shekhar Sharma
Keywords
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