Serum paraoxonase-1 activities and malondialdehyde levels in patients with epilepsy
Journal Title: Dicle Tıp Dergisi - Year 2012, Vol 39, Issue 4
Abstract
Objectives: We aimed to evaluate antioxidant paraoxonase- 1 (PON-1) activity together with malondialdehyde (MDA) (an oxidative stress parameter) levels in patients with epilepsy. Materials and methods: Forty-five epilepsy patients were included in the study and compared with healthy controls (n = 45). The levels of serum MDA and PON-1 activities were measured by the Ohkawa method and the Eckerson method, respectively. Results: Serum MDA level was significantly higher (P = 0.015), whereas PON-1 activity was sigificantly lower (P = 0.011) in the patient group than the controls. Conclusions: Increased reactive oxygen species levels in epilepsy may result in a oxidative stress, which in turn could result in decreased antioxidant PON-1 activity and increased MDA levels. Key words: Epilepsy, oxidative stress, malondialdehyde, paraoxonase-1
Authors and Affiliations
Mehmet Çevik, Sefer Varol, Yavuz Yücel, Eşref Akıl, Tahsin Çelepkolu, Adalet Arıkanoğlu, Hatice Yüksel
Keywords
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