Serum Uric Acid Levels as a Risk Stratification Tool in Hypertensive Pregnancy
Journal Title: Indian Obstetrics & Gynaecology - Year 2016, Vol 6, Issue 4
Abstract
Objective: To compare serum uric acid levels in normal pregnant and pregnancy induced hypertension (PIH) women and to correlate serum uric acid levels (SUA) with severity of PIH and with maternal & foetal complications. Material and method: 125 pregnant women attending antenatal clinic, with PIH of different severity and between 20 to 40 weeks of gestation, confirmed by ultrasound, and equal number of matched healthy normotensive pregnant women served as case and controls respectively. Women with essential hypertension, diabetes mellitus, renal disorder, liver disorder, epilepsy, urinary tract infection and gout were excluded. Blood samples were collected from study subjects for estimation of serum uric acid concentration by fully automatic biochemical analyser. Observations & results: The age and parity in both groups were comparable though in case group majority were nullipara (78.4%). Mean serum uric level in case group was 5.0 ± 1.74 mg/dl compared to 2.66 ± 0.39 mg/dl in control (p < 0.001). Serum uric acid levels also tend to increase with increasing severity of pregnancy induced hypertension. Maternal complications during antepartum and postpartum period was higher once SUA > 5 mg/dl was taken as a cut-off. Proteinuria, coagulopathy, need for transfusion, eclampsia and related problems were significantly more. Significantly lower birth weight, low APGAR score at 1 minute and higher NICU admission were also observed in neonates. Morbidity to mothers and babies were significantly higher. Conclusion: Higher than 5 mg/dl levels of serum uric acid may serve as a risk stratification tool for identification of mother and foetuses at higher risk of morbidity and mortality in pregnancy induced hypertensive disorders.
Authors and Affiliations
Shivani Agarwal, Dr. Sangita Nangia Ajmani, Dr. Pooja Rani Luthra
Keywords
Related Articles
- EP ID EP457436
- DOI -
- Views 86
- Downloads 0
An Atypical Aggressive Presentation of a Malignant Endodermal Sinus Tumour in a Young Girl - A Case Report
Malignant ovarian germ cell tumours (OGCT) comprise only 2-5% of all ovarian malignant cancers. Endodermal sinus tumour (Yolk sac tumour-YST) is the second most common malignant germ cell tumour of the ovary after dysger...
A Review of Medical Treatment of Ectopic Pregnancy with Systemic Methotrexate
Introduction: The aim of this review is to reassess the effectiveness of systemic methotrexate for the treatment of selected cases of ectopic pregnancy. Materials & Methods: A retrospective review of 21 cases of ectopic...
Pseudo- Broad Ligament Angiolipoleiomyoma Mimicking Ovarian Torsion - A Rare Case Report
We report a rare case of pseudo-broad ligament angiolipoleiomyoma mimicking torsion of ovarian tumour as per clinical and radiological findings. A 28-years-old female P2L2 presented in emergency department with complaint...
Incidental urethral stone in sub urethral space : A case report
Urethral stones are rare urinary tract stones which account for less than 2% of all the cases. They occur almost exclusively in men but rare cases in women have also been reported. We report a case of urethral stone in s...
IMPORTANCE OF DEVELOPING A NEW MODIFIED HIGH RISK PREGNANCY SCORING SYSTEM
Objective: The present study is an attempt to propose a new modified high risk pregnancy scoring system incorporating both maternal and foetal risk factors by assigning a numerical score to each woman and to assess the e...