SERUM VASCULAR ENDOTHELIAL GROWTH FACTOR LEVELS IN NORMAL EARLY PREGNANCIES AND RECURRENT ABORTION PATIENTS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 46
Abstract
BACKGROUND Adequate angiogenesis is required for successful continuation of pregnancy and Vascular Angiogenic Growth Factor (VEGF) is one of the most important pro-angiogenic factors regulating early placental vascular changes. MATERIALS AND METHODS This is a descriptive comparative study. The correlation of angiogenic factor - Vascular Endothelial Growth Factor (VEGF) with recurrent abortion was evaluated in North Indian pregnant women for 60 patients with a history of Recurrent Abortion (RA) (Study group) and 60 normal pregnant women of early pregnancy (Control group) through this descriptive comparative study. The blood samples of the patients were collected to assess the serum level of VEGF by Enzyme-Linked Immunoassay (ELISA) technique Human VEGF-A BIOLISA kit. The concentration of circulating VEGF-A was evaluated by using Mann-Whitney U tests. The quantitate assay used in the present study analysed VEGF-165 isoform, which is a diffusible isoform of VEGF. RESULTS This variation was staggering being many times lower in RA as compared to normal early pregnant women. CONCLUSION The study concluded that alteration (Decreased) in the levels of VEGF may be related with RA.
Authors and Affiliations
Renu Baliyan Jeph, Sneh Agarwal, Vijender Jeph, Smita Kakar, Usha Gupta, Anita Tuli
Keywords
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- EP ID EP548038
- DOI 10.14260/jemds/2018/1111
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